In molecular biology, glycoside hydrolase family 78 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 78 CAZY GH_78 includes enzymes with α-L-rhamnosidase EC 3.2.1.40 activity. This family includes bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.[8]
^Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. Bibcode:1995PNAS...92.7090H. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
^Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
^Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
^"Home". CAZy.org. Retrieved 2018-03-06.
^Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
^"Glycoside Hydrolase Family 78". CAZypedia.org. Retrieved 2018-03-06.
^CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. hdl:21.11116/0000-0003-B7EB-6. PMID 29040563.
^Zverlov VV, Hertel C, Bronnenmeier K, Hroch A, Kellermann J, Schwarz WH (January 2000). "The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase". Mol. Microbiol. 35 (1): 173–9. doi:10.1046/j.1365-2958.2000.01691.x. PMID 10632887. S2CID 24638480.
and 23 Related for: Glycoside hydrolase family 78 information
In molecular biology, glycosidehydrolasefamily78 is a family of glycosidehydrolases. Glycosidehydrolases EC 3.2.1. are a widespread group of enzymes...
In molecular biology, glycosidehydrolasefamily 26 is a family of glycosidehydrolases. Glycosidehydrolases EC 3.2.1. are a widespread group of enzymes...
In molecular biology, Glycosidehydrolasefamily 19 is a family of glycosidehydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse...
In molecular biology, glycosidehydrolasefamily 5 is a family of glycosidehydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse...
Igarashi K, Samejima M, et al. (March 2010). "Crystal structure of a glycosidehydrolasefamily 6 enzyme, CcCel6C, a cellulase constitutively produced by Coprinopsis...
bacteria. The mechanism of OBPgp279 is predicted to be part of glycosidehydrolasefamily 19 (GH19) due to the presence of a conserved sequence motif (general...
link to elevated transaminase levels. Acarbose inhibits enzymes (glycosidehydrolases) needed to digest carbohydrates, specifically, alpha-glucosidase...
classical glycosidehydrolases (which belong to CAZy family GH31), and is exemplified by the sulfoquinovosidase YihQ from Escherichia coli. Family GH31 sulfoquinovosidases...
synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two...
beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycosidehydrolase". J. Mol. Biol. 370 (5): 964–75. doi:10.1016/j.jmb.2007.05.034...
another paracetamol metabolite 4-aminophenol by action of fatty acid amide hydrolase. AM404 is a weak agonist of cannabinoid receptors CB1 and CB2, an inhibitor...
into the digestive fluid they produce. By studying phosphatase, glycosidehydrolase, glucanase, RNAse and chitinase enzymes as well as a pathogenesis-related...
Homestyle Arabian Cooking. Tuttle Publishing. ISBN 9781462905249. "Cyanogenic glycosides – Information Sheet" (PDF). New Zealand Food Safety Authority. 2006. Archived...
Cannabis (/ˈkænəbɪs/) is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be...
et al. (2006). "Understanding the polymerization mechanism of glycoside-hydrolasefamily 70 glucansucrases". Journal of Biological Chemistry. 281 (42):...
perforatum, commonly known as St John's wort, is a flowering plant in the family Hypericaceae. It is a perennial plant that grows up to one meter tall, with...
include proteases that digest proteins into amino acids, as well as glycosidehydrolases that digest polysaccharides into simple sugars known as monosaccharides...
transfer a functional group (e.g. a methyl or phosphate group) EC 3, Hydrolases: catalyze the hydrolysis of various bonds EC 4, Lyases: cleave various...
of the genus Polaribacter show a high prevalence of peptidase and glycosidehydrolase genes in comparison to other bacteria in the Flavobacteriaceae, indicating...
K, Roy Chowdhury A, Chatterjee R, Chakravortty D, 2022, GH18 familyglycosidehydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion...
Global Information