In molecular biology, glycoside hydrolase family 24 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 24 CAZY GH_24 comprises enzymes with only one known activity; lysozyme (EC 3.2.1.17). This family includes lambda phage lysozyme and Escherichia coli T4 phage endolysin.[8] Lysozyme helps to release mature phage particles from the cell wall by breaking down the peptidoglycan. The enzyme hydrolyses the 1,4-beta linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls. E. coli endolysin also functions in bacterial cell lysis and acts as a transglycosylase. The T4 lysozyme structure contains 2 domains, the interface between which forms the active-site cleft. The N-terminus of the 2 domains undergoes a 'hinge-bending' motion about an axis passing through the molecular waist.[8][9] This mobility is thought to be important in allowing access of substrates to the enzyme active site.
^Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. Bibcode:1995PNAS...92.7090H. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
^Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
^Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
^"Home". CAZy.org. Retrieved 2018-03-06.
^Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490-5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
^"Glycoside Hydrolase Family 24". CAZypedia.org. Retrieved 2018-03-06.
^CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes" (PDF). Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.
^ abWeaver LH, Matthews BW (January 1987). "Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution". Journal of Molecular Biology. 193 (1): 189–99. doi:10.1016/0022-2836(87)90636-X. PMID 3586019.
^Faber HR, Matthews BW (November 1990). "A mutant T4 lysozyme displays five different crystal conformations". Nature. 348 (6298): 263–6. Bibcode:1990Natur.348..263F. doi:10.1038/348263a0. PMID 2234094. S2CID 4266149.
and 24 Related for: Glycoside hydrolase family 24 information
In molecular biology, glycosidehydrolasefamily24 is a family of glycosidehydrolases. Glycosidehydrolases EC 3.2.1. are a widespread group of enzymes...
In molecular biology, glycosidehydrolasefamily 92 is a family of glycosidehydrolases. Glycosidehydrolases EC 3.2.1. are a widespread group of enzymes...
In molecular biology, glycosidehydrolasefamily 38 is a family of glycosidehydrolases. Glycosidehydrolases EC 3.2.1. are a widespread group of enzymes...
amylopectin. They belong to glycosidehydrolasefamily 13 (https://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_13). Because it can act anywhere...
sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycosidehydrolase that cleaves the glycosidic linkages of neuraminic acids:...
Igarashi K, Samejima M, et al. (March 2010). "Crystal structure of a glycosidehydrolasefamily 6 enzyme, CcCel6C, a cellulase constitutively produced by Coprinopsis...
Da.[citation needed] β-Glucocerebrosidase is a member of the glycosidehydrolasefamily 30 and consists of three distinct domains (I-III). Three-dimensional...
occur naturally and are used for the fluorimetric determination of glycosidehydrolase enzymes. Isoprenylated derivatives are also widespread, such as marmin...
revealed five enzyme families involved in the synthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P450s...
Gregg, Katie J (16 October 2015). "Structural Analysis of a Family 101 GlycosideHydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism"...
link to elevated transaminase levels. Acarbose inhibits enzymes (glycosidehydrolases) needed to digest carbohydrates, specifically, alpha-glucosidase...
classical glycosidehydrolases (which belong to CAZy family GH31), and is exemplified by the sulfoquinovosidase YihQ from Escherichia coli. Family GH31 sulfoquinovosidases...
binds the virus to the infected cell. Neuraminidase is a type of glycosidehydrolase enzyme which helps to move the virus particles through the infected...
includes just a single gene from the glycosidehydrolasefamily 9 (GH9) and a few from the glycosidehydrolasefamily 1 (GH1). This genetic makeup is somewhat...
another paracetamol metabolite 4-aminophenol by action of fatty acid amide hydrolase. AM404 is a weak agonist of cannabinoid receptors CB1 and CB2, an inhibitor...
synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two...
β-linked sugars and use them as the sole carbon source by encoding many glycosidehydrolases. It is presumed to secrete cellulases to break down plant-matter...
hexosyltransferases. More specifically it has been placed in the retaining glycosidehydrolasesfamily although it catalyzes a transglycosidation rather than hydrolysis...
and JmjC-family histone demethylases. Cellular proteins with the double jelly roll fold include glycosidehydrolases of the DUF2961 family, peptide:N-glycosidase...
principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as a herbal supplement, cosmetics ingredient...
The enzymes used to cleave the glycosidic linkage in cellulose are glycosidehydrolases including endo-acting cellulases and exo-acting glucosidases. Such...
Global Information