GPX8 information

GPX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CYN, 3KIJ
Identifiers
Aliases	GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)
External IDs	OMIM: 617172; MGI: 1916840; HomoloGene: 88454; GeneCards: GPX8; OMA:GPX8 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,167,297 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,182,944 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; tibia; ; germinal epithelium; ; placenta; ; smooth muscle tissue; ; Achilles tendon; ; parietal pleura; ; gonad; ; synovial membrane; ; corpus epididymis;
	Top expressed in
	calvaria; ; belly cord; ; efferent ductule; ; Epithelium of choroid plexus; ; vestibular sensory epithelium; ; decidua; ; interventricular septum; ; uterus; ; intercostal muscle; ; cervix;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; peroxidase activity;
Cellular component	integral component of membrane; endoplasmic reticulum lumen; membrane;
Biological process	response to oxidative stress; cellular oxidant detoxification; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	493869
	69590
	ENSG00000164294
	ENSMUSG00000021760
	Q8TED1
	Q9D7B7
	NM_001008397; NM_001306197; NM_001306198; NM_001306201
	NM_027127
	NP_001008398; NP_001293126; NP_001293127; NP_001293130
	NP_081403
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.^[5]^[6] GPx-8 is a member of the glutathione peroxidase family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: glutathione peroxidase 8 (putative)".
^ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: glutathione peroxidase 8 (putative)".

[pmid18498225-6] Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.