Tenosynovial giant cell tumor (TGCT) is a group of rare, typically non-malignant tumors of the joints. TGCT tumors often develop from the lining of joints (also known as synovial tissue).[1][2][2]: 100[3][3]: 245.
Common symptoms of TGCT include swelling, pain, stiffness and reduced mobility in the affected joint or limb.[2]: 102 This group of tumors can be divided into different subsets according to their site, growth pattern, and prognosis.[4][4]: 361 Localized/nodular TGCT is sometimes referred to as giant cell tumor of the tendon sheath;[2]: 100 diffuse TGCT is also called pigmented villonodular synovitis (PVNS).[2]: 102These two distinct subtypes determined by radiographic appearance.[5] Localized TGCT is defined as a well circumscribed tumor while diffuse TGCT exhibits a locally aggressive and infiltrative behavior.[6]
^Lucas, David R. (2012). "Tenosynovial Giant Cell Tumor: Case Report and Review". Archives of Pathology & Laboratory Medicine. 136 (8): 901–906. doi:10.5858/arpa.2012-0165-CR. PMID 22849738.
^ abcdeFletcher, C. D.M.; Bridge, J.A.; Hogendoorn, P.; Mertens, F. (2013). WHO Classification of Tumours of Soft Tissue and Bone. Fourth Edition. World Health Organization. ISBN 9789283224341. Archived from the original on July 19, 2016.
^ abRateb, Kochbati; Hassen, Ben Ghozlen; Leila, Abid; Faten, Farah; Med Samir, Daghfous (2017). "Giant cell tumor of soft tissues: A case report of extra-articular diffuse-type giant cell tumor of the quadriceps". International Journal of Surgery Case Reports. 31: 245–249. doi:10.1016/j.ijscr.2016.12.019. PMC 5310176. PMID 28199932.
^ abRavi, Vinod; Wang, Wei-Lien; Lewis, Valerae O. (2011). "Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis". Current Opinion in Oncology. 23 (4): 361–366. doi:10.1097/CCO.0b013e328347e1e3. PMID 21577109. S2CID 1608847.
^Stacchiotti, Silvia; Dürr, Hans Roland; Schaefer, Inga-Marie; Woertler, Klaus; Haas, Rick; Trama, Annalisa; Caraceni, Augusto; Bajpai, Jyoti; Baldi, Giacomo Giulio; Bernthal, Nicholas; Blay, Jean-Yves; Boye, Kjetil; Broto, Javier-Martin; Chen, Wei-Wu Tom; Dei Tos, Paolo Angelo (January 2023). "Best clinical management of tenosynovial giant cell tumour (TGCT): A consensus paper from the community of experts". Cancer Treatment Reviews. 112: 102491. doi:10.1016/j.ctrv.2022.102491. hdl:10067/1923310151162165141. PMID 36502615.
^Palmerini, Emanuela; Staals, Eric L.; Maki, Robert G.; Pengo, Stefano; Cioffi, Angela; Gambarotti, Marco; Picci, Piero; Daolio, Primo Andrea; Parafioriti, Antonina; Morris, Carol; Antonescu, Cristina R.; Gronchi, Alessandro; Casali, Paolo Giovanni; Donati, Davide M.; Ferrari, Stefano (January 2015). "Tenosynovial giant cell tumour/pigmented villonodular synovitis: Outcome of 294 patients before the era of kinase inhibitors". European Journal of Cancer. 51 (2): 210–217. doi:10.1016/j.ejca.2014.11.001. PMID 25465190.
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