Micrograph of a seminoma, a common germ cell tumor.
Specialty
Oncology
Germ cell tumor (GCT) is a neoplasm derived from the primordial germ cells.[1] Germ-cell tumors can be cancerous or benign. Germ cells normally occur inside the gonads (ovary[2] and testis). GCTs that originate outside the gonads may be birth defects resulting from errors during development of the embryo.
^Harrison's principles of internal medicine (21st ed.). New York: McGraw Hill. 2022. p. 690. ISBN 978-1-264-26850-4.
^Maoz A, Matsuo K, Ciccone MA, Matsuzaki S, Klar M, Roman LD, et al. (May 2020). "Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review". Cancers. 12 (6): 1398. doi:10.3390/cancers12061398. PMC 7353025. PMID 32485873.
Germcelltumor (GCT) is a neoplasm derived from the primordial germcells. Germ-celltumors can be cancerous or benign. Germcells normally occur inside...
A germcell is any cell that gives rise to the gametes of an organism that reproduces sexually. In many animals, the germcells originate in the primitive...
ovary is made up of three different cell types including epithelial cells, germcells, and stromal cells. When these cells become abnormal, they have the ability...
testicular torsion, or hydrops fetalis. They are a type of germcelltumor (a tumor that begins in the cells that give rise to sperm or eggs). They are divided...
An extracranial germcelltumor (EGCT) occurs in the abnormal growth of germcells in the gonads (testes or ovaries) and the areas other than the brain...
Ovarian germcelltumors (OGCTs) are heterogeneous tumors that are derived from the primitive germcells of the embryonic gonad, which accounts for about...
More than 95% are germcelltumors which are divided into seminomas and non-seminomas. Other types include sex-cord stromal tumors and lymphomas. Diagnosis...
A seminoma is a germcelltumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a malignant neoplasm and is one...
risk factors for testicular germcelltumor, the increase in risk of concurrent diagnosis of testicular germcelltumor, or testicular carcinoma-in-situ...
divided into germcelltumors and non–germcelltumors. Germcelltumors are further categorized as either seminomas or nonseminomatous tumors. Other malignant...
cancer Extragonadal germcelltumor Ovarian cancer Ovarian epithelial cancer (surface epithelial-stromal tumor) Ovarian germcelltumor Penile cancer Kidney...
marrow, which also frequently presents as one or more bone lesions. Germcelltumors, including teratoma, often present and originate in the midline of...
Tumor antigen is an antigenic substance produced in tumorcells, i.e., it triggers an immune response in the host. Tumor antigens are useful tumor markers...
Embryonal carcinoma is a relatively uncommon type of nonseminomatous germcell tumour that occurs in the ovaries and testes. The presenting features may...
stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically...
A germinoma is a type of germ-celltumor, which is not differentiated upon examination. It may be benign or malignant. Germinomas are thought to originate...
A dysgerminoma is a type of germcelltumor; it usually is malignant and usually occurs in the ovary. A tumor of the identical histology but not occurring...
as there is a risk of reduced fertility or infertility. Testicular germcelltumors (TGCT) accounts for 95% of cases of testicular cancer in young men...
gestational trophoblastic disease (GTD). It is also classified as a germcelltumor and may arise in the testis or ovary. increased quantitative chorionic...
the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. Current...
teratoma (MCT) is a benign (non-cancerous) tumor that develops from at least two of the embryonic germcell layers. They are characterized by a lining...
of tumors, and even predicting drug-response and monitor therapy. Tumor markers can be molecules that are produced in higher amounts by cancer cells than...
is less common than metastasis arising from ovarian epithelial and germ-celltumors.[citation needed] In people who have had nongynecologic malignancy...
involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread...
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