Intratubular germ cell neoplasia (ITGCN or IGCN), testicular intratubular germ cell neoplasia, intratubular germ cell neoplasia of the testis
Intratubular germ cell neoplasia. H&E stain.
Specialty
Pathology, urology
Germ cell neoplasia in situ (GCNIS) represents the precursor lesion for many types of testicular germ cell tumors.[1]
The term GCNIS was introduced with the 2016 edition of the WHO classification of urological tumours.[1] GCNIS more accurate describes the lesion as it arises between the basement membrane and Sertoli cells (the cells that 'nurse' the developing germ cell). The common, unspecified variant of the entity was once considered to be a carcinoma in situ,[2] although the term "carcinoma in situ" is now largely historical as it is not an accurate description of the process.[3]
^ abWilliamson, Sean R; Delahunt, Brett; Magi-Galluzzi, Cristina; Algaba, Ferran; Egevad, Lars; Ulbright, Thomas M; Tickoo, Satish K; Srigley, John R; Epstein, Jonathan I; Berney, Daniel M (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
^Dieckmann KP, Skakkebaek NE (December 1999). "Carcinoma in situ of the testis: review of biological and clinical features". Int. J. Cancer. 83 (6): 815–22. doi:10.1002/(SICI)1097-0215(19991210)83:6<815::AID-IJC21>3.0.CO;2-Z. PMID 10597201.
^Mills, S (ed.) 2009.Sternberg's Diagnostic Pathology. 5th Edition. ISBN 978-0-7817-7942-5
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