Online database of genome-wide association study results
The GWAS catalog is a free online database that compiles data of genome-wide association studies (GWAS), summarizing unstructured data from different literature sources into accessible high quality data.[1] It was created by the National Human Genome Research Institute (NHGRI) in 2008 and have become a collaborative project between the NHGRI and the European Bioinformatics Institute (EBI) since 2010.[1] As of September 2018, it has included 71,673 SNP–trait associations in 3,567 publications.[2]
A GWAS identifies genetic loci associated with common traits and disease through the analysis of categorized variants across the genome and the catalog provides information from all published GWAS results that meet its criteria.[3] The catalog contains publication information, study groups information (origin, size) and SNP-disease association information (including SNP identifier, P-value, gene and risk allele).[4] Over the years, the GWAS catalog has enhanced its data release frequency by adding features such as graphical user interface, ontology-supported search functionality and a curation interface.[3]
The GWAS catalog is widely used to identify causal variants and understand disease mechanisms by biologists, bioinformaticians and other researchers.[4][5][6][7][8] Some GWAS identified common genomic loci that are associated diseases include: cardiovascular disease, inflammatory bowel disease, type 2 diabetes and breast cancer.[3]
^ ab"About the GWAS Catalog". GWAS Catalog. Retrieved 2019-06-17.
^Buniello A, MacArthur JA, Cerezo M, Harris LW, Hayhurst J, Malangone C, et al. (January 2019). "The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019". Nucleic Acids Research. 47 (D1): D1005–D1012. doi:10.1093/nar/gky1120. PMC 6323933. PMID 30445434.
^ abcMacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, et al. (January 2017). "The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)". Nucleic Acids Research. 45 (D1): D896–D901. doi:10.1093/nar/gkw1133. PMC 5210590. PMID 27899670.
^ abWelter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, et al. (January 2014). "The NHGRI GWAS Catalog, a curated resource of SNP-trait associations". Nucleic Acids Research. 42 (Database issue): D1001-6. doi:10.1093/nar/gkt1229. PMC 3965119. PMID 24316577.
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Loos RJ, Yeo GS (January 2014). "The bigger picture of FTO: the first GWAS-identified obesity gene". Nature Reviews. Endocrinology. 10 (1): 51–61. doi:10.1038/nrendo.2013.227. PMC 4188449. PMID 24247219.
^López-Cortegano E, Caballero A (July 2019). "Inferring the Nature of Missing Heritability in Human Traits Using Data from the GWAS Catalog". Genetics. 212 (3): 891–904. doi:10.1534/genetics.119.302077. PMC 6614893. PMID 31123044. Retrieved 7 Nov 2019.
^Pal LR, Moult J (July 2015). "Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies". Journal of Molecular Biology. 427 (13): 2271–89. doi:10.1016/j.jmb.2015.04.014. PMC 4893807. PMID 25937569.
The GWAScatalog is a free online database that compiles data of genome-wide association studies (GWAS), summarizing unstructured data from different literature...
SNPs. That is why GWAS use customizable arrays (SNP chips) to genotype only a subset of the variants identified as tag snps. Most GWAS use products from...
association studies (GWAS). It is funded through the GEN2PHEN project by the European Union under their Seventh Framework Programme. GWAS Central contains...
1186/1471-2105-14-228. PMC 3722091. PMID 23865855. Welter, D. (2014). "The NHGRI GWASCatalog, a curated resource of SNP-trait associations". Nucleic Acids Research...
(gnomAD) Genome Sequence Archive (GSA) NHGRI-EBI Catalog of human genome-wide association studies (GWASCatalog) Gene Expression Database (GXD) HGNC: HUGO Gene...
Genomes MyGene.info National Center for Biotechnology Information BioGRID GWASCatalog AnimalQTLdb Ensembl database of automatically annotated genomic data...
in J Macarthur et al., "The new NHGRI-EBI Catalog of published genome-wide association studies (GWASCatalog)," Nucleic Acids Research, vol 45, issue D1...
Protein | HNRC1 Antibody". www.genecards.org. Retrieved 1 May 2020. "GWASCatalog". www.ebi.ac.uk. Retrieved 3 May 2020. Trachoo O, Assanatham M, Jinawath...
Medicine. Retrieved 3 Dec 2023. "The NHGRI-EBI Catalog of human genome-wide association studies". GWASCatalog. Retrieved 10 Dec 2023. Hiam D, Simar D, Laker...
ancestry data in genomics studies, with application to the NHGRI-EBI GWASCatalog". doi:10.3410/f.732698975.793550674. S2CID 69505888. {{cite journal}}:...
infected with common warts compared to normal skin. 10 SNPs from the GWAScatalog associate c12orf71 gene with obsolete and androgenic alopecia, healing...
estimated effect sizes derived from a genome-wide association study (GWAS). In a GWAS, single-nucleotide polymorphisms (SNPs) are tested for an association...
researchers often do a study called a "genome-wide association study" (GWAS). A GWAS study will look at one disease, and then sequence the genome of many...
TCF12 has been speculatively related to human male sexuality through a GWAS study indicating association to a related single nucleotide polymorphism...
genome and whose results can be used in studies of association with diseases (GWAS) such as diabetes, cardiovascular or autoimmune diseases. A total of 26 ethnic...
Hepburn Romanization System in Japanese Language Cataloging: Where to Look, What to Follow" (pdf). Cataloging & Classification Quarterly. 49 (2): 97–120. doi:10...
June 23, 2005. Retrieved July 31, 2015 Die Attachment, Fluid Dispensing catalog from SPT small precision tools "Die bonding techniques and methods". 9...
donors selected from the Hypertension Genetic Epidemiology Network (HyperGEN) GWAS study. The company's first product, iCell Cardiomyocytes, have been used...
The Great Western Arms Company (GWA) was founded in Los Angeles, California in 1953 to produce an American-made copy of the Colt Single Action Army Revolver...
mice prevented the side effects. He has also reported on meta-analyses of GWAS studies of aging and disease, identifying the major histocompatibility complex...
Daniel J. M.; Bodmer, Walter F. (11 August 2020). "Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants". Proceedings...
Global Information