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Neopterin information


Neopterin
Names
Preferred IUPAC name
2-Amino-6-(1,2,3-trihydroxypropyl)pteridin-4(1H)-one
Identifiers
CAS Number
  • 2009-64-5 checkY
3D model (JSmol)
  • Interactive image
  • Interactive image
ChemSpider
  • 395518 checkY
DrugBank
  • DB02385 checkY
ECHA InfoCard 100.016.296 Edit this at Wikidata
MeSH Neopterin
PubChem CID
  • 448839
UNII
  • 9PLD60N7SO checkY
InChI
  • InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1 checkY
    Key: BMQYVXCPAOLZOK-XINAWCOVSA-N checkY
SMILES
  • O=C2\N=C(/Nc1ncc(nc12)[C@H](O)[C@H](O)CO)N
  • C1=C(N=C2C(=N1)NC(=NC2=O)N)C(C(CO)O)O
Properties
Chemical formula
C9H11N5O4
Molar mass 253.215 g/mol
Density 2.02 g/cm3
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Neopterin is an organic compound belonging to the pteridine class of heterocyclic compounds.

Neopterin belongs to the chemical group known as pteridines. It is synthesised by human macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin serves as a marker of cellular immune system activation.[1] In humans neopterin follows a circadian and circaseptan rhythm.[2]

  1. ^ Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis Progress in Neuro-Psychopharmacology and Biological Psychiatry 2023. 120:110633. http://dx.doi.org/10.1016/j.pnpbp.2022.110633
  2. ^ Seizer L, Cornélissen-Guillaume G, Schiepek GK, Chamson E, Bliem HR and Schubert C (2022) About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis. Front. Psychiatry 13:799214. doi: 10.3389/fpsyt.2022.799214

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Neopterin

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Neopterin is an organic compound belonging to the pteridine class of heterocyclic compounds. Neopterin belongs to the chemical group known as pteridines...

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Tetrahydrobiopterin

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1021/CR9402034. PMID 11848840. Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis...

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C9H11N5O4

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refer to: Eritadenine, a chemical compound found in shiitake mushrooms Neopterin, a catabolic product of guanosine triphosphate This set index page lists...

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Kynurenine pathway

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tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms". Journal of Acquired Immune...

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Juvenile dermatomyositis

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capillaroscopy, factor VIII-related antigen, muscle ultrasound, calcinosis and neopterin. Once a diagnosis of JDMS is made, the treatment is often a 3-day course...

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Tyrosine hydroxylase

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1987). "Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of...

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Biology of depression

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Increased numbers of T-Cells presenting activation markers, levels of neopterin, IFN-γ, sTNFR, and IL-2 receptors have been observed in depression. Various...

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Biopterin

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2007-06-29. Retrieved 2007-06-07. Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis...

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Autosomal recessive GTP cyclohydrolase I deficiency

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hyperphenylalaninemia, and usually have decreased levels of biopterin and neopterin in urine and in dry blood spots. According to a consensus guideline published...

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Index of immunology articles

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Monospecific antibody Mucosal immunology MYD88 Myokine Neoantigenic determinant Neopterin Neuroimmune system Neuroimmunology Neutralisation (immunology) NFAT Nicotinamide...

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John Raymond Hobbs

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Henderson D.C., Sheldon J., Riches P.G., Hobbs J.R. Cytokine induction of neopterin production, Clin Exp Immunol 1991; 83: 479–482 497 Wang Q., Rowbottom...

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Sepiapterin reductase deficiency

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of HVA and HIAA and high concentrations of sepiapterin in the CSF, but neopterin and biopterin were abnormal in only one sibling. The results of this research...

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Hereditary folate malabsorption

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biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations". Molecular Genetics and Metabolism. 95 (3): 127–32. doi:10...

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Environmental enteropathy

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(lactose-to-mannitol ratio) Intestinal inflammation Alpha-1 anti-trypsin Neopterin Myeloperoxidase Exocrine (hormonal) markers Bacterial translocation markers...

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