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RPH3A information


RPH3A
Identifiers
AliasesRPH3A
External IDsOMIM: 612159; MGI: 102788; HomoloGene: 7921; GeneCards: RPH3A; OMA:RPH3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143854
NM_014954

NM_011286
NM_001302344
NM_001302345

RefSeq (protein)

NP_001289273
NP_001289274
NP_035416

Location (UCSC)n/aChr 5: 121.08 – 121.15 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene.[4][5][6] It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.[7]

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029608 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (July 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  5. ^ Inagaki N, Mizuta M, Seino S (February 1995). "Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells". J Biochem. 116 (2): 239–42. doi:10.1093/oxfordjournals.jbchem.a124512. PMID 7822236.
  6. ^ "Entrez Gene: RPH3A rabphilin 3A homolog (mouse)".
  7. ^ Deák F, Shin OH, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC (2006). "Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion". EMBO J. 25 (12): 2856–66. doi:10.1038/sj.emboj.7601165. PMC 1500841. PMID 16763567.

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RPH3A

Last Update:

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration...

Word Count : 1097

RAB3A

Last Update:

exocytosis in neurons. RAB3A has been shown to interact with: RIMS1, UNC13A, RPH3A, and CHM. GRCh38: Ensembl release 89: ENSG00000105649 – Ensembl, May 2017...

Word Count : 1256

CASK

Last Update:

and TBR1 DLG1 DLG4 F11 receptor ID1 KCNJ12 LIN7A Nephrin Parkin (ligase) RPH3A SDC2 CASK Research Foundation - A non-profit based in the UK for research...

Word Count : 2890

C2 domain

Last Update:

RASA4; RASAL1; RASAL2; RGS3; RIMS1; RIMS2; RIMS3; RIMS4; RPGRIP1; RPGRIP1L; RPH3A; SGA72M; SMURF1; SMURF2; SYNGAP1; SYT1; SYT10; SYT11; SYT12; SYT13; SYT14;...

Word Count : 1059

RAB3B

Last Update:

humans is encoded by the RAB3B gene. RAB3B has been shown to interact with RPH3A. GRCh38: Ensembl release 89: ENSG00000169213 – Ensembl, May 2017 GRCm38:...

Word Count : 813

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