In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission.
A GABAergic or GABAnergic agent is any chemical that modifies the effects of GABA in the body or brain. Some different classes of GABAergic drugs include agonists, antagonists, modulators, reuptake inhibitors and enzymes.[1]
^Froestl, Wolfgang (2011). "An historical perspective on GABAergic drugs". Future Medicinal Chemistry. 3 (2): 163–175. doi:10.4155/fmc.10.285. ISSN 1756-8919. PMID 21428811.
is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it...
neurons (MSNs), which are the principal neurons of the striatum. They are GABAergic and, thus, are classified as inhibitory neurons. Medium spiny projection...
for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons. Its molecular formula is C 5H 9NO 4. Glutamic acid exists in...
are located on the axon terminal of the presynaptic neuron, mainly at GABAergic and glutamatergic synapses. Neurotransmission is regulated by several...
nucleoside analogs such as EdU. In 2008, a nomenclature for the features of GABAergic cortical interneurons was proposed, called Petilla terminology. Ia inhibitory...
neurotransmitter such as excitatory dopaminergic neurons and inhibitory GABAergic neurons. Cortical interneurons only make up around a fifth of the neuronal...
used. The striatum is composed mostly of medium spiny neurons. These GABAergic neurons project to the external (lateral) globus pallidus and internal...
needed] Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism...
Connectivity diagram showing excitatory glutamatergic pathways as red, inhibitory GABAergic pathways as blue, and modulatory dopaminergic as magenta....
RMTg) projects to the VTA with GABAergic afferents, functioning as a "master brake" for the VTA dopamine pathways. GABAergic inputs to the VTA also include...
cells are primarily GABAergic, while the large vertical cells and radial cells are primarily glutamatergic. The descriptors GABAergic and glutamatergic...
those of the globus pallidus, the neurons in pars reticulata are mainly GABAergic.[citation needed] The main input to the SNpr derives from the striatum...
relation to ICSS behavior: monoaminergic drugs, opioids, cholinergic drugs, GABAergic drugs, as well as a small number of drugs from other classes. These studies...
from other neurotransmitters systems, including glutaminergic inputs, GABAergic inputs, cholinergic inputs, and inputs from other monoaminergic nuclei...
dendritic processes radiating from the cell body. Many stellate cells are GABAergic and are located in the molecular layer of the cerebellum. Stellate cells...
their production, and the GEs contribute significantly to building up the GABAergic cortical cell population. Another structure that the GEs contribute to...
neurons in the VLPO that project to the ascending arousal system are GABAergic (neurons that produce GABA). In vitro studies in rats have shown that...
neurotransmitter in the central nervous system. Accurate regulation of GABAergic transmission through appropriate developmental processes, specificity...
types of amacrine cells into subtypes. GABAergic, glycinergic, or neither: Amacrine cells can be either GABAergic, glycinergic or neither depending on what...
also known as spiny projection neurons (SPNs), are a special type of GABAergic inhibitory cell representing 95% of neurons within the human striatum...
of this pathway release dopamine from axon terminals that synapse onto GABAergic medium spiny neurons (MSNs), also known as spiny projection neurons (SPNs)...
is relatively further (lateral) from the midline of the brain. The GPe GABAergic neurons, allow for its inhibitory function and projects axons to the subthalamic...
allosteric modulation and agonism of several GABAAR subtypes. Similar to other GABAergic agents, methaqualone will produce tolerance and physical dependence with...
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