N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4).[5][6] Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor.
^ abcGRCh38: Ensembl release 89: ENSG00000171049 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000052270 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (Mar 1997). "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor". The Journal of Biological Chemistry. 272 (11): 6972–8. doi:10.1074/jbc.272.11.6972. PMID 9054386.
^"Entrez Gene: FPR2 formyl peptide receptor 2".
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