phospholipase C-activating G protein-coupled receptor signaling pathway
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
nitric oxide mediated signal transduction
G protein-coupled receptor signaling pathway
signal transduction
chemotaxis
complement receptor mediated signaling pathway
inflammatory response
positive regulation of cytosolic calcium ion concentration
neutrophil degranulation
leukocyte migration
cell chemotaxis
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2357
14293
Ensembl
ENSG00000171051
ENSMUSG00000045551
UniProt
P21462
P33766
RefSeq (mRNA)
NM_002029 NM_001193306
NM_013521
RefSeq (protein)
NP_001180235 NP_002020
NP_038549
Location (UCSC)
Chr 19: 51.75 – 51.8 Mb
Chr 17: 18.1 – 18.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) gene. This gene encodes a G protein-coupled receptor cell surface protein that binds and is activated by N-Formylmethionine-containing oligopeptides, particularly N-Formylmethionine-leucyl-phenylalanine (FMLP). FPR1 is prominently expressed by mammalian phagocytic and blood leukocyte cells where it functions to mediate these cells' responses to the N-formylmethionine-containing oligopeptides which are released by invading microorganisms and injured tissues. FPR1 directs these cells to sites of invading pathogens or disrupted tissues and then stimulates these cells to kill the pathogens or to remove tissue debris; as such, it is an important component of the innate immune system that operates in host defense and damage control.[5]
Humans also express two paralogs of FPR1 vis., FPR2 and FPR3. Mice express no fewer than 7 Fpr receptors and encoding genes that are homologous to FPR1 although no single one of these FPRs appears to perform exactly the same functions as any one of the human FPRs.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000171051 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045551 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Formyl peptide receptor 1".
^Cite error: The named reference Migeotte_2006 was invoked but never defined (see the help page).
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