Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine.[2][3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning.[3][4] It is taken by mouth, injection into a muscle, or injection into a vein.[3]
Side effects may include trouble sleeping, allergic reactions, or fever.[2][3] Use in pregnancy or breastfeeding is generally regarded as safe.[2] When used for anemia it is recommended that pernicious anemia as a cause be ruled out first.[3] Folinic acid is a form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.[3]
Folinic acid was first made in 1945.[5] It is on the World Health Organization's List of Essential Medicines.[6]
^"Safety Data Sheet Folinic Acid (calcium salt)" (PDF). Retrieved 25 January 2018.
^ abcBritish national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 576–577. ISBN 9780857111562.
^ abcdef"Leucovorin Calcium". The American Society of Health-System Pharmacists. Archived from the original on 10 May 2017. Retrieved 8 December 2016.
^Munjal YP, Sharm SK (2012). API Textbook of Medicine, Ninth Edition, Two Volume Set. JP Medical Ltd. p. 1945. ISBN 9789350250747. Archived from the original on 10 May 2017.
^Sneader W (2005). Drug Discovery: A History. John Wiley & Sons. p. 235. ISBN 9780471899792. Archived from the original on 10 May 2017.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Folinicacid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination...
folinicacid, folacin, and pteroylglutamic acid. Historic names included L. casei factor, vitamin Bc and vitamin M. The terms folate and folic acid have...
February 2020. Pyrimethamine is typically given with a sulfonamide and folinicacid. It is used for the treatment of toxoplasmosis, actinomycosis, and isosporiasis...
needed. During pregnancy, spiramycin or pyrimethamine/sulfadiazine and folinicacid may be used for treatment. Up to half of the world's population is infected...
chemotherapy regimen for treatment of colorectal cancer, made up of the drugs folinicacid (leucovorin, FOL), fluorouracil (5-FU, F), and oxaliplatin (Eloxatin...
by folate, the cerebral deficiency remains and must be treated with folinicacid. Folate deficiency can occur during pregnancy as a result of the increasing...
Oxaliplatin is used for treatment of colorectal cancer, typically along with folinicacid (leucovorin) and fluorouracil in a combination known as FOLFOX or along...
treatment of colorectal cancer. It is made up of the following drugs: FOL – folinicacid (leucovorin), a vitamin B derivative with multiple applications, which...
the chemical transformation of folic acid into its active form, folinicacid, this can be treated by folinicacid given at 20–200 mg daily. Due to variances...
or threatened, treatment consists of pyrimethamine, sulfadiazine, and folinicacid for 4–6 weeks. Prednisone is sometimes used to decrease inflammation...
by folate, the cerebral deficiency remains and must be treated with folinicacid. Success depends on early initiation of treatment and treatment for a...
factor, gene of Neurospora crassa Fluorouracil (5-FU), and leucovorin (folinicacid), a chemotherapy regimen Follicular lymphoma in medicine Frontal lobe...
The chemotherapy regimen is made up of the following four drugs: FOL – folinicacid (leucovorin), a vitamin B derivative that modulates/potentiates/reduces...
the chemical transformation of folic acid into its active form, folinicacid, this can be treated by folinicacid given at 20–200 mg daily. Lagrange et...
pancreatic cancer. It is made up of the following four drugs: FOL – folinicacid (leucovorin), a vitamin B derivative that enhances the effects of 5-fluorouracil...
similar in principle. Both consist of 3 medicinal drugs: a) Leucovorin (= folinicacid = calcium folinate), b) 5-Fluorouracil (= 5-FU), and c) Oxaliplatin....
hemodiafiltration to remove methanol and formate from the blood. Folinicacid or folic acid is also administered to enhance the metabolism of formate. There...
approved aflibercept (Zaltrap) for use in combination with 5-fluorouracil, folinicacid and irinotecan to treat adults with metastatic colorectal cancer that...
deficiency have marked improvements in their clinical status when taking folinicacid. A series of five children with cerebral folate deficiency and low functioning...
the class of vitamin A vitamers which include retinol, retinal, retinoic acid, and provitamin carotenoids such as beta-carotene among others. Vitamers...
Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (FolinicAcid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis"...
have shown that these neurodevelopmental disorders can be treated with folinicacid. SLC19A1 ONX-0801 GRCh38: Ensembl release 89: ENSG00000110195 – Ensembl...
capecitabine and irinotecan. It may also be used together with fluorouracil and folinicacid for pancreatic cancer following failure of initial treatment. In February...
four doses of intramuscular along with an intramuscular injection of folinicacid to protect cells from the effects of the drugs and to reduce side effects...
Global Information
(what is this?) (verify)