neural crest cell migration involved in heart formation
axon regeneration
COPII vesicle coating
endoplasmic reticulum to Golgi vesicle-mediated transport
heart looping
cardiac neural crest cell migration involved in outflow tract morphogenesis
pharyngeal arch artery morphogenesis
folic acid metabolic process
regulation of transforming growth factor beta receptor signaling pathway
response to axon injury
regulation of canonical Wnt signaling pathway
anterior neural tube closure
folic acid transport
transport
folate import across plasma membrane
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2348
14275
Ensembl
ENSG00000110195
ENSMUSG00000001827
UniProt
P15328
P35846
RefSeq (mRNA)
NM_016730 NM_000802 NM_016724 NM_016725 NM_016729
NM_001252552 NM_001252553 NM_001252554 NM_008034
RefSeq (protein)
NP_000793 NP_057936 NP_057937 NP_057941
NP_001239481 NP_001239482 NP_001239483 NP_032060
Location (UCSC)
Chr 11: 72.19 – 72.2 Mb
Chr 7: 101.51 – 101.52 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene.[5][6]
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells.
^ abcGRCh38: Ensembl release 89: ENSG00000110195 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001827 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Campbell IG, Jones TA, Foulkes WD, Trowsdale J (October 1991). "Folate-binding protein is a marker for ovarian cancer". Cancer Research. 51 (19): 5329–38. PMID 1717147.
Folatereceptor1 (Folatereceptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member...
Folatereceptors bind folate and reduced folic acid derivatives and mediates delivery of tetrahydrofolate to the interior of cells. It is then converted...
autoantibodies to the folatereceptor. For people with the FOLR1 mutation, even when the systemic deficiency is corrected by folate, the cerebral deficiency...
of folate compounds into mammalian cells can occur via receptor-mediated (see folatereceptor1) or carrier-mediated mechanisms. A functional coordination...
Folate deficiency, also known as vitamin B9 deficiency, is a low level of folate and derivatives in the body. This may result in a type of anemia in which...
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as...
vitamin, folate (folic acid), to a molecule/drug to form a "folate conjugate". Based on the natural high affinity of folate for the folatereceptor protein...
Folatereceptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid. The FOLR multi-gene family (FOLR1...
Folatereceptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folatereceptor (FOLR)...
molecule drug conjugate consisting of a small molecule targeting the folatereceptor, which is overexpressed on certain cancers, such as ovarian cancer...
disorders. One form of CFD is due to loss-of-mutations in folatereceptor-α, (FRα), which transports folates via an endocytic process. While PCFT is expressed...
fluorescence-guided surgery. Pafolacianine is a fluorescent medication that binds to folatereceptor (FR)-expressing cells. The most common side effects of pafolacianine...
molecule drug conjugate consisting of a small molecule targeting the folatereceptor, which is expressed on many cancers, such as ovarian cancer, and a...
chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that...
cancer, or primary peritoneal cancer. Mirvetuximab soravtansine is a folatereceptor alpha directed antibody and microtubule inhibitor conjugate. The most...
and tend to have adverse effects on the bone marrow, skin, and hair. As folate is vital in the first trimester of pregnancy for healthy fetal development...
implicated in neural tube defects. Vitamin B12 is also an important receptor in the folate biopathway such that studies have shown deficiency in vitamin B12...
avoided because folic acid tightly binds to the folatereceptor alpha and may inhibit the transport of folate into the central nervous system. Opladen T,...
It is decreased with methyl folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate, and a decrease in formiminoglutamic...
Global Information
