Chemotherapy regimen for colorectal cancer treatment
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer. It is made up of the following drugs:[1]
FOL – folinic acid (leucovorin), a vitamin B derivative with multiple applications, which in this context decreases the cytotoxicity of 5-fluorouracil;
F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops synthesis; and
IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating.
^Chen, K; Gong, Y; Zhang, Q; Shen, Y; Zhou, T (2016). "Efficacy and safety of addition of bevacizumab to FOLFIRI or irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer: A meta-analysis". Medicine. 95 (46): e5221. doi:10.1097/MD.0000000000005221. PMC 5120901. PMID 27861344.
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer. It is made up of the following drugs: FOL – folinic acid (leucovorin), a vitamin...
Aflibercept (Zaltrap), in combination with fluorouracil, leucovorin, irinotecan (FOLFIRI), is indicated for the treatment of people with metastatic colorectal cancer...
bevacizumab can be followed by fluoropyrimidine with bevacizumab maintenance. FOLFIRI FOLFOX FOLFIRINOX IFL Nipp RD, Ryan DP (2015). "Should FOLFOXIRI plus bevacizumab...
Patient's ability to conceive offspring may be affected by treatment. FOLFIRI FOLFIRINOX IFL "FOLFOX". Cancer Research UK. Archived from the original...
combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan...
compared ramucirumab plus irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) to FOLFIRI alone. In May 2019, ramucirumab was approved by FDA as a single agent...
Access Scheme (PAS) proposal, which would bring down the cost of the drug. FOLFIRI FOLFOX FOLFOXIRI IFL Moran, R. G.; Keyomarsi, K. (1987). "Biochemical rationale...
Some specific regimens used for CRC are CAPOX, FOLFOX, FOLFOXIRI, and FOLFIRI. Antiangiogenic drugs such as bevacizumab are often added in first line...
Satoshi (2015-03-01). "A Case of Metastatic Urachal Carcinoma Treated With FOLFIRI (irinotecan and 5-Fluorouracil/leucovorin) Plus Bevacizumab". Urology Case...
Global Information