This article is about the bleeding disorder with factor IX deficiency. For the disorder with factor VIII deficiency, see haemophilia A.
Medical condition
Haemophilia B
Other names
Hemophilia B, Christmas disease
This condition is inherited in an X-linked recessive manner.
Specialty
Haematology
Symptoms
Easy bruising[1]
Causes
Factor IX deficiency[1]
Diagnostic method
Bleeding scores, Coagulation factor assays[2]
Treatment
Factor IX concentrate[1]
Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A).[3]
Haemophilia B was first recognized as a distinct disease entity in 1952.[4] It is also known by the eponym Christmas disease,[1] named after Stephen Christmas, the first patient described with haemophilia B. In addition, the first report of its identification was published in the Christmas edition of the British Medical Journal.[4][5]
Most individuals who have Hemophilia B and experience symptoms are men.[6] The prevalence of Hemophilia B in the population is about one in 40,000; Hemophilia B represents about 15% of patients with hemophilia.[6] Many women carriers of the disease have no symptoms.[6] However, an estimated 10-25% of women carriers have mild symptoms; in rare cases, women may have moderate or severe symptoms.[6]
^ abcd"Hemophilia B: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2016-09-21.
^Cite error: The named reference konk was invoked but never defined (see the help page).
^Kliegman, Robert (2011). Nelson textbook of pediatrics (19th ed.). Philadelphia: Saunders. pp. 1700–1. ISBN 978-1-4377-0755-7.
^ ab"Haemophilia B (Factor IX Deficiency) information | Patient". Patient. 3 July 2014. Retrieved 2016-04-21.
^Biggs R, Douglas AS, MacFarlane RG, Dacie JV, Pitney WR, Merskey C, O'Brien JR (1952). "Christmas disease: a condition previously mistaken for haemophilia". Br Med J. 2 (4799): 1378–82. doi:10.1136/bmj.2.4799.1378. PMC 2022306. PMID 12997790.
^ abcd"FDA Approves First Gene Therapy to Treat Adults with Hemophilia B". U.S. Food and Drug Administration (FDA). 22 November 2022. Retrieved 22 November 2022. This article incorporates text from this source, which is in the public domain.
HaemophiliaB, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for...
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specific form of haemophilia passed down by Queen Victoria was probably the relatively rare haemophiliaB. The presence of haemophiliaB within the European...
and haemophilia A and B. In the United States, it is thought to affect 1 in 100,000 of the adult population, making it 10% as common as haemophilia A....
haemophiliaB. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia....
Victoria's youngest son, Leopold, was affected by the blood-clotting disease haemophiliaB and at least two of her five daughters, Alice and Beatrice, were carriers...
April 1984) was an Argentinian physician who discovered that haemophilia has two types (A and B). Pavlovsky graduated with his medical degree in 1931, then...
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The first successful use of gene transfer to convert severe to mild haemophiliaB was reported by his group in December 2011.He retired from Directorship...
have been a haemophiliac himself or would have had a mutated gene. HaemophiliaB has been known to arise spontaneously in the children of older fathers...
(b. 1900) Wilhelm Burgdorf, German general (suicide) (b. 1895) Hans Krebs, German general (suicide) (b. 1898) Prince Waldemar of Prussia (haemophilia)...
essential role in blood coagulation, and deficiency leads to the disease haemophiliaB of which treatment requires intravenous infusion of factor IX. The production...
pandemic and whether more could have been done. A potential cure for haemophiliaB is announced by British doctors, which corrects the genetic defect associated...
attaching to the DNA of people with a rare and unusual form of HaemophiliaB – HaemophiliaB Leyden – where sufferers experience episodes of excessive bleeding...
Transfusion Service. It had also been discovered that a second form of haemophilia (HaemophiliaB) existed, which was treatable with blood protein called Factor...
Gwyn Macfarlane and colleagues publish the first identification of HaemophiliaB. American obstetrical anesthesiologist Dr. Virginia Apgar devises the...
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