crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein.
Identifiers
Symbol
FERM_N
Pfam
PF09379
Pfam clan
CL0072
InterPro
IPR018979
SCOP2
1gc7 / SCOPe / SUPFAM
OPM superfamily
49
OPM protein
1gc6
Membranome
161
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
FERM central domain
crystal structure of the protein 4.1r membrane binding domain
Identifiers
Symbol
FERM_M
Pfam
PF00373
InterPro
IPR019748
SCOP2
1gc7 / SCOPe / SUPFAM
CDD
cd14473
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
FERM C-terminal PH-like domain
crystal structure of the radixin ferm domain complexed with the nep cytoplasmic tail
Identifiers
Symbol
FERM_C
Pfam
PF09380
Pfam clan
CL0266
InterPro
IPR018980
SCOP2
1ef1 / SCOPe / SUPFAM
CDD
cd00836
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane.[1] FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found.[1][2]
^ abChishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB (August 1998). "The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane". Trends Biochem. Sci. 23 (8): 281–2. doi:10.1016/S0968-0004(98)01237-7. PMID 9757824.
^Pearson MA, Reczek D, Bretscher A, Karplus PA (April 2000). "Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain". Cell. 101 (3): 259–70. doi:10.1016/S0092-8674(00)80836-3. PMID 10847681. S2CID 7119092.
In molecular biology, the FERMdomain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising...
FERMDomain Containing 4B is a gene, located on human Chromosome 3 at 3p14.1, that encodes FERMDomain Containing Protein 4b. "FRMD4B FERMdomain containing...
FERMDomain Containing 4A is a gene, located on human Chromosome 10 at 10p13, that encodes FERMDomain Containing Protein 4A. GRCh38: Ensembl release 89:...
FERMdomain containing 4B is a protein that in humans is encoded by the FRMD4B gene. This gene encodes a GRP1-binding protein which contains a FERM protein...
canoeist Vergilius Ferm (1896–1974), American philosopher FERMdomain Ferme (disambiguation) This page lists people with the surname Ferm. If an internal...
(NH2) end (JH4-JH7) of Jaks is called a FERMdomain (short for band 4.1, ezrin, radixin and moesin); this domain is also found in the focal adhesion kinase...
Myo10 FERMdomain can bind to the cytoplasmic domains of several β-integrins, a major class of cell adhesion receptor, and to the cytoplasmic domains of...
the following three domains: N-terminal globular domain, also called FERMdomain (Band 4.1, ezrin, radixin, moesin). The FERMdomain allows ERM proteins...
similarity to kinases from other subfamilies. It also includes a large FERMdomain. With the exception of certain types of blood cells, most cells express...
Kibra-Ex-Mer (KEM) complex. Both Ex and Mer are FERMdomain-containing proteins, while Kibra, like Sav, is a WW domain-containing protein. The KEM complex physically...
each contain a bipartite FERMdomain comprising four subdomains F0, F1, F2, and F3 that show homology with the FERM head (H) domain of the cytoskeletal Talin...
cell–cell recognition and signaling and for cell movement. Moesin has FERMdomain at N-terminal. Moesin has been shown to interact with: CD43 ICAM3 Neutrophil...
P-villin from binding to the FERMdomain of nonphosphorylated protein. The intramolecular interaction between the FERM and SH2 domains of nonphosphorylated Jak3...
FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene. This gene encodes a multi-domain (WW, PDZ, FERM) containing...
N-terminus of ezrin contains a FERMdomain which is further subdivided into three subdomains. The C-terminus contains an ERM domain. The cytoplasmic peripheral...
Hakoshima T (2001). "Crystallographic characterization of the radixin FERMdomain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr...
FRMD4B is a gene which codes for FERMDomain Containing 4B, a scaffolding protein. It is found at chromosome 3p14.1. "Human PubMed Reference:". National...
FERMdomain-containing protein 7 is a protein that in humans is encoded by the FRMD7 gene. GRCm38: Ensembl release 89: ENSMUSG00000036131 – Ensembl, May...
homologous to members of the ERM protein family which have a globular FERMdomain (residues 86-400) that links the actin cytoskeleton to adhesion proteins...
FERMdomain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene. GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May...
FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene. This gene encodes a peripheral membrane protein and is located...
mice is found in synapses and focal adhesion plaques, and binds the FERMdomain of talin through its C-terminus. GRCh38: Ensembl release 89: ENSG00000186111...
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene. FARP2 has been shown to interact with...
homologous domain, DUF3338, which is found in eukaryotes. A portion of the multiple sequence alignment is shown below. Apart from the DUF domain (boxed in...
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