Ezrin information

EZR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RM8, 4RMA, 4RM9, 1NI2
Identifiers
Aliases	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
External IDs	OMIM: 123900; MGI: 98931; HomoloGene: 55740; GeneCards: EZR; OMA:EZR - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	158,819,368 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,050,183 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; bronchial epithelial cell; ; ganglionic eminence; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; tendon of biceps brachii; ; right adrenal cortex; ; right uterine tube; ; jejunal mucosa;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; left colon; ; epithelium of small intestine; ; intestinal villus; ; ileum; ; seminal vesicula; ; Ileal epithelium; ; pyloric antrum; ; Epithelium of choroid plexus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein-containing complex binding; cytoskeletal protein binding; protein kinase A regulatory subunit binding; protein kinase A catalytic subunit binding; S100 protein binding; actin filament binding; protein binding; cell adhesion molecule binding; microtubule binding; ATPase binding; actin binding; RNA binding; cadherin binding; protein C-terminus binding; disordered domain specific binding; protein kinase A binding; identical protein binding;
Cellular component	cytoplasm; cytosol; endosome; membrane; focal adhesion; T-tubule; ruffle; Schwann cell microvillus; ruffle membrane; actin cytoskeleton; perinuclear region of cytoplasm; cytoskeleton; cell projection; cytoplasmic side of apical plasma membrane; myelin sheath; microvillus; microspike; apical plasma membrane; membrane raft; extracellular exosome; microvillus membrane; ciliary basal body; filopodium; cortical cytoskeleton; plasma membrane; apical part of cell; astrocyte projection; intracellular anatomical structure; cell cortex; brush border; actin filament; TCR signalosome; cell periphery; cell body; vesicle; plasma membrane raft; uropod; basolateral plasma membrane; immunological synapse; cell tip; fibrillar center; extracellular space; extrinsic component of membrane; protein-containing complex;
Biological process	leukocyte cell-cell adhesion; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; negative regulation of p38MAPK cascade; actin filament bundle assembly; establishment of epithelial cell apical/basal polarity; positive regulation of multicellular organism growth; astral microtubule organization; cellular response to cAMP; establishment of endothelial barrier; microvillus assembly; negative regulation of T cell receptor signaling pathway; gland morphogenesis; cortical microtubule organization; positive regulation of protein localization to early endosome; positive regulation of early endosome to late endosome transport; intestinal D-glucose absorption; establishment or maintenance of apical/basal cell polarity; regulation of NIK/NF-kappaB signaling; epithelial cell differentiation; regulation of actin cytoskeleton organization; negative regulation of transcription by RNA polymerase II; positive regulation of protein secretion; membrane to membrane docking; regulation of cell shape; protein kinase A signaling; establishment of centrosome localization; phosphatidylinositol-mediated signaling; regulation of cell size; actin cytoskeleton reorganization; filopodium assembly; receptor internalization; terminal web assembly; axon guidance; positive regulation of gene expression; negative regulation of ERK1 and ERK2 cascade; protein localization to cell cortex; regulation of microvillus length; protein localization to plasma membrane; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	7430
	22350
	ENSG00000092820
	ENSMUSG00000052397
	P15311
	P26040
	NM_001111077; NM_003379
	NM_009510
	NP_001104547; NP_003370
	NP_033536
	Wikidata
View/Edit Human	View/Edit Mouse

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092820 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092820 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052397 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591371-5] Gould KL, Bretscher A, Esch FS, Hunter T (December 1989). "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". EMBO J. 8 (13): 4133–42. doi:10.1002/j.1460-2075.1989.tb08598.x. PMC 401598. PMID 2591371.

Ezrin information

and 16 Related for: Ezrin information

Bob Ezrin

Ezrin

The Wall

A Momentary Lapse of Reason

Welcome to My Nightmare

Hershell Ezrin

DaDa

Another Brick in the Wall

ERM protein family

Love It to Death

In the Spirit of Things

Two Steps from the Move

Imperial Triumphant

The Division Bell

Welcome 2 My Nightmare

Nobody Home