EIF3M information

EIF3M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J8B, 3J8C, 5A5T
Identifiers
Aliases	EIF3M, B5, PCID1, TANGO7, hfl-B5, GA17, eukaryotic translation initiation factor 3 subunit M
External IDs	OMIM: 609641; MGI: 1351744; HomoloGene: 4639; GeneCards: EIF3M; OMA:EIF3M - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	32,606,264 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	104,847,425 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; superficial temporal artery; ; parietal pleura; ; body of pancreas; ; ganglionic eminence; ; left ovary; ; oral cavity; ; monocyte; ; epithelium of nasopharynx; ; endometrium;
	Top expressed in
	epiblast; ; ovary; ; pancreas; ; embryo; ; ventricular zone; ; ganglionic eminence; ; embryo; ; islet of Langerhans; ; uterus; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor binding; protein binding; translation initiation factor activity;
Cellular component	cytoplasm; eukaryotic translation initiation factor 3 complex; cytosol; eukaryotic translation initiation factor 3 complex, eIF3m; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex;
Biological process	translational initiation; cytoplasmic translational initiation; protein biosynthesis; formation of cytoplasmic translation initiation complex;
	Sources:Amigo / QuickGO
Orthologs
	10480
	98221
	ENSG00000149100
	ENSMUSG00000027170
	Q7L2H7
	Q99JX4
	NM_001307929; NM_006360
	NM_145380
	NP_001294858; NP_006351
	NP_663355
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.^[5]^[6]

HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV).^[5]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149100 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027170 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PCID1 PCI domain containing 1 (herpesvirus entry mediator)".
^ Gawin B, Niederführ A, Schumacher N, Hummerich H, Little PF, Gessler M (November 1999). "A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1". Genome Res. 9 (11): 1074–86. doi:10.1101/gr.9.11.1074. PMC 310838. PMID 10568747.
^ Perez A, Li QX, Perez-Romero P, Delassus G, Lopez SR, Sutter S, McLaren N, Fuller AO (June 2005). "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins". J. Virol. 79 (12): 7419–30. doi:10.1128/JVI.79.12.7419-7430.2005. PMC 1143644. PMID 15919898.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149100 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027170 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PCID1 PCI domain containing 1 (herpesvirus entry mediator)".

[pmid10568747-6] Gawin B, Niederführ A, Schumacher N, Hummerich H, Little PF, Gessler M (November 1999). "A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1". Genome Res. 9 (11): 1074–86. doi:10.1101/gr.9.11.1074. PMC 310838. PMID 10568747.

[pmid15919898-7] Perez A, Li QX, Perez-Romero P, Delassus G, Lopez SR, Sutter S, McLaren N, Fuller AO (June 2005). "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins". J. Virol. 79 (12): 7419–30. doi:10.1128/JVI.79.12.7419-7430.2005. PMC 1143644. PMID 15919898.

EIF3M information

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EIF3M

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