Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer.[2] It is also used for hemophagocytic lymphohistiocytosis.[3] It is used by mouth or injection into a vein.[2]
Side effects are very common.[2] They can include low blood cell counts, vomiting, loss of appetite, diarrhea, hair loss, and fever.[2] Other severe side effects include allergic reactions and low blood pressure.[2][4] Use during pregnancy will likely harm the fetus.[2] Etoposide is in the topoisomerase inhibitor family of medication.[2] It is believed to work by damaging DNA.[2]
Etoposide was approved for medical use in the United States in 1983.[2] It is on the World Health Organization's List of Essential Medicines.[5]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abcdefghi"Etoposide". The American Society of Health-System Pharmacists. Archived from the original on 31 March 2016. Retrieved 8 December 2016.
^Yildiz H, Van Den Neste E, Defour JP, Danse E, Yombi JC (January 2020). "Adult haemophagocytic lymphohistiocytosis: a Review". QJM. 115 (4): 205–213. doi:10.1093/qjmed/hcaa011. PMID 31943120.
^World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 227. hdl:10665/44053. ISBN 9789241547659.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including...
platinum-based chemotherapy and radiation therapy. In combination with etoposide and either carboplatin or cisplatin, as first-line treatment for adults...
Foudeh, M; Pai, C; Allam, A; El Hassan, I; Ezzat, A (October 2004). "VIP (etoposide, ifosfamide, cisplatin) in adult patients with recurrent or refractory...
some being natural products first extracted from plants (camptothecin, etoposide) or bacterial samples (doxorubicin, indolocarbazole), while others possess...
warts, and two of its derivatives, etoposide and teniposide, have shown promise in treating some cancers. Etoposide is among the World Health Organisations's...
limitations of CPT derivatives and are currently in clinical trials. Etoposide (Fig. 7) and its close relative teniposide (VM-26) are epipodophyllotoxin...
derivatives are currently used in the treatment of cancer. These include etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase...
topoisomerase II (Topo II) during the late S and early G2 stage. For instance, etoposide binds and stabilizes the temporary DNA break caused by the enzyme, disrupts...
monoclonal antibody that kills both normal and malignant B-lymphocytes Etoposide, an epipodophyllotoxin topoisomerase inhibitor Solu-Medrol - Methylprednisolone...
used to produce two other drugs with different mechanisms of action: etoposide and teniposide. Topoisomerase inhibitors are drugs that affect the activity...
hormone Evoked potential, a stimulation induced electrophysiological test Etoposide and platinum agent (cisplatin), a chemotherapy regimen Extreme pressure...
platinum-based chemotherapeutic – cisplatin or carboplatin – combined with either etoposide or irinotecan. This is typically combined with thoracic radiation therapy...
nucleotides Daunorubicin, Doxorubicin, Epirubicin Enzyme inhibitors inhibit enzymes that are crucial to DNA replication Decitabine, Etoposide, Irinotecan...
chemotherapy protocol is three, or sometimes four, rounds of Bleomycin-Etoposide-Cisplatin (BEP). BEP as a first-line treatment was first reported by Professor...
commonly used in GCTs is called PEB (or BEP), and consists of bleomycin, etoposide, and a platinum-based antineoplastic (cisplatin). Targeted treatments...
AML-M5, has been associated with exposure to epipodophyllotoxins, such as etoposide. Many cases of AML-M5 are seen to have enhanced phosphorylation of the...
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