Epipodophyllotoxins are substances naturally occurring in the root of American Mayapple plant (Podophyllum peltatum).
Some epipodophyllotoxin derivatives are currently used in the treatment of cancer. These include etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase II.[1]
^Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy" Archived 2009-05-15 at the Wayback Machine in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach Archived 2013-10-04 at the Wayback Machine. 11 ed. 2008.
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Epipodophyllotoxins are substances naturally occurring in the root of American Mayapple plant (Podophyllum peltatum). Some epipodophyllotoxin derivatives...
Curran DP (June 1981). "Total synthesis of (.+-.)-4'-demethyl-4-epipodophyllotoxin by insertion-cyclization". The Journal of Organic Chemistry. 46 (13):...
h. Excretion Kidney and fecal Identifiers IUPAC name 4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4' -(dihydrogen phosphate)...
Etoposide (Fig. 7) and its close relative teniposide (VM-26) are epipodophyllotoxin derivatives obtained from the rhizome of wild mandrake that target...
that kills both normal and malignant B-lymphocytes Etoposide, an epipodophyllotoxin topoisomerase inhibitor Solu-Medrol - Methylprednisolone, which is...
resulting in the discovery of the camptothecin, anthracycline and epipodophyllotoxin classes. Knowledge of the first topoisomerase inhibitors, and their...
during the period of 1970 to 1990, including anthracyclines and epipodophyllotoxins — both of which inhibited the action of topoisomerase II, an enzyme...
which may include AML-M5, has been associated with exposure to epipodophyllotoxins, such as etoposide. Many cases of AML-M5 are seen to have enhanced...
individuals treated with certain types of chemotherapy, such as epipodophyllotoxins and cyclophosphamide. There is some evidence that a common infection...
related, NOS Therapy-related acute myeloid leukemia, alkylating agent/epipodophyllotoxin related M9930/3 Chloroma or Myeloid sarcoma (see also M9861/3) Granulocytic...
antineoplastic agent Etoposide- a topoisomerase inhibitor from the epipodophyllotoxin group Procarbazine - an alkylating antineoplastic agent Prednisone...
malignancies, radiation therapy, alkylating antineoplastic agents, and epipodophyllotoxins are not used, and methotrexate can be used only with caution; the...
(December 1991). "Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia". The New England Journal of Medicine...
mechanisms of action of chemotherapeutic drugs including camptothecin, epipodophyllotoxins, and bleomycin, and taxol. Horwitz's work on taxol in particular...
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