Ethosuximide, sold under the brand name Zarontin among others, is a medication used to treat absence seizures.[4] It may be used by itself or with other antiseizure medications such as valproic acid.[4] Ethosuximide is taken by mouth.[4]
Ethosuximide is usually well tolerated.[5] Common side effects include loss of appetite, abdominal pain, diarrhea, and feeling tired.[4] Serious side effects include suicidal thoughts, low blood cell levels, and lupus erythematosus.[4][5] It is unclear if it has adverse effects on the fetus during pregnancy.[4] Ethosuximide is in the succinimide family of medications. Its mechanism of action is thought to be due to antagonism of the postsynaptic T-type voltage-gated calcium channel.[6]
Ethosuximide was approved for medical use in the United States in 1960.[7] It is on the World Health Organization's List of Essential Medicines.[8] Ethosuximide is available as a generic medication.[4] As of 2019 its availability was limited in many countries with concerns of price fixing in the United States.[9][10][11]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^"List of nationally authorised medicinal products" (PDF). European Medicines Agency.
^Cite error: The named reference bioavailability was invoked but never defined (see the help page).
^ abcdefg"Ethosuximide". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ abWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 69, 74–75. hdl:10665/44053. ISBN 9789241547659.
^Huguenard, John R. (March 2002). "Block of T -Type Ca2+ Channels Is an Important Action of Succinimide Antiabsence Drugs". Epilepsy Currents. 2 (2): 49–52. doi:10.1046/j.1535-7597.2002.00019.x. PMC 320968. PMID 15309165.
^"Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration. Retrieved 29 December 2020.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^Cite error: The named reference Hem2019 was invoked but never defined (see the help page).
^"Attorney General Tong leads 44-state coalition in antitrust lawsuit against Teva Pharmaceuticals, 19 other generic drug manufacturers, 15 individuals in conspiracy to fix prices and allocate markets for more than 100 different generic drugs" (Press release). Office of the Attorney General of the State of Connecticut. 12 May 2019. Retrieved 5 April 2020.
^Cite error: The named reference CA2019 was invoked but never defined (see the help page).
Ethosuximide, sold under the brand name Zarontin among others, is a medication used to treat absence seizures. It may be used by itself or with other antiseizure...
absence seizures in that T-type Ca++ channels are believed to be involved. Ethosuximide is specific for these channels and thus it is not effective for treating...
uses. Several succinimides are used as anticonvulsant drugs, including ethosuximide, phensuximide, and methsuximide. Succinimides are also used to form covalent...
showed that valproate and ethosuximide had similar absence-free rate after 16 weeks of treatment. In addition, ethosuximide did not increase attentional...
Vermont, United States ESX-1, an Electribe electronic musical instrument Ethosuximide, an anti epileptic drugs paper ESX-1, a pore-forming protein system of...
Levetiracetam (1999). Seletracetam. The following are succinimides: Ethosuximide (1955). Phensuximide. Mesuximide. Acetazolamide (1953). Sultiame. Methazolamide...
Mellon University Energy Saving Module Enterprise systems management Ethosuximide, an antiepileptic drug European Service Module, part of the Orion spacecraft...
doses, or in combination with other drugs, such as opioids or alcohol. Ethosuximide and perampanel can also produce euphoria at therapeutic doses. μ-Opioid...
liver, leading to increased valproate concentrations. Ethosuximide: valproate may increase ethosuximide concentrations and lead to toxicity. Felbamate: may...
anticonvulsants (such as phenytoin, phenobarbital, lamotrigine, vigabatrin, ethosuximide, topiramate and primidone NOT common for valproate) calcium channel blockers...
with lamotrigine being second-line. In those with absence seizures, ethosuximide or valproate are recommended; valproate is particularly effective in...
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