Chemical compound
Not to be confused with Estramustine phosphate or Estramustine.
Estromustine Other names EoM; Leo 271 f; Estrone 17β-3-N-bis(2-chloroethyl)carbamate; Estrone–cytostatic complex Drug class Chemotherapeutic agent; Estrogen; Estrogen ester Elimination half-life 14 hours[1]
[(8R ,9S ,13S ,14S )-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H -cyclopenta[a ]phenanthren-3-yl] N ,N -bis(2-chloroethyl)carbamate
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) DTXSID40978673 Formula C 23 H 29 Cl 2 N O 3 Molar mass 438.39 g·mol−1 3D model (JSmol)
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
InChI=1S/C23H29Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-20H,2,4,6-13H2,1H3/t18-,19-,20+,23+/m1/s1
Key:AXWYROHIFVWHMR-UGTOYMOASA-N
Estromustine (developmental code name Leo 271 f ), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex ,[2] is a major active metabolite of the cytostatic antineoplastic agent and estrogen estramustine phosphate, a medication used in the treatment of prostate cancer.[1] [3]
^ a b Chabner BA, Longo DL (7 December 2011). Cancer Chemotherapy and Biotherapy: Principles and Practice . Lippincott Williams & Wilkins. pp. 252–. ISBN 978-1-4511-4820-6 .
^ Yamanaka H, Kitaura K, Imai K, Yuasa H, Nakai K, Matsumura Y, Uehara H, Shida K (1981). "In vivo studies of 3H-estramustine in castrated male rat". Acta Urologica Japonica . 27 (3): 243–50.
^ Medical Subject Headings: Supplementary chemical records . The Library. 1993. p. 684.
Last Update: 2022-11-27T19:14:28Z
Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex, is a major active...
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Last Update: 2023-12-20T19:57:16Z
anticancer agent of the estrogen type. It is a prodrug of estramustine and estromustine in terms of its cytostatic effects and a prodrug of estradiol in relation...
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Last Update: 2024-03-18T14:50:10Z
Estriol esters Polyestriol phosphate Estrofurate Estrogenic substances Estromustine Estrone Estrone esters Estrone methyl ether Estropipate Etamestrol (eptamestrol)...
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Last Update: 2023-12-20T19:57:13Z
C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine , estradiol, and estrone, is marketed and used in the treatment of prostate...
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Estriol esters Polyestriol phosphate Estrofurate Estrogenic substances Estromustine Estrone Estrone esters Estrone methyl ether Estropipate Etamestrol (eptamestrol)...
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Estriol esters Polyestriol phosphate Estrofurate Estrogenic substances Estromustine Estrone Estrone esters Estrone methyl ether Estropipate Etamestrol (eptamestrol)...
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