Enzyme that metabolizes compounds containing epoxides
microsomal epoxide hydrolase
Identifiers
EC no.
3.3.2.9
CAS no.
9048-63-9
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
soluble epoxide hydrolase
Epoxide hydrolase from Mycobacterium tuberculosis.[1]
Identifiers
EC no.
3.3.2.10
CAS no.
9048-63-9
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Epoxide hydrolases (EHs), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue to two hydroxyl residues through an epoxide hydrolysis reaction to form diol products. Several enzymes possess EH activity. Microsomal epoxide hydrolase (epoxide hydrolase 1, EH1, or mEH), soluble epoxide hydrolase (sEH, epoxide hydrolase 2, EH2, or cytoplasmic epoxide hydrolase), and the more recently discovered but not as yet well defined functionally, epoxide hydrolase 3 (EH3) and epoxide hydrolase 4 (EH4) are structurally closely related isozymes. Other enzymes with epoxide hydrolase activity include leukotriene A4 hydrolase, Cholesterol-5,6-oxide hydrolase, MEST (gene) (Peg1/MEST), and Hepoxilin-epoxide hydrolase.[2] The hydrolases are distinguished from each other by their substrate preferences and, directly related to this, their functions.
^PDB: 2E3J; Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN (September 2008). "The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor". Journal of Molecular Biology. 381 (4): 897–912. doi:10.1016/j.jmb.2008.06.030. PMC 2866126. PMID 18585390.; rendered via PyMOL
^Morisseau C (January 2013). "Role of epoxide hydrolases in lipid metabolism". Biochimie. 95 (1): 91–5. doi:10.1016/j.biochi.2012.06.011. PMC 3495083. PMID 22722082.
Epoxidehydrolases (EHs), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue...
Soluble epoxidehydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxidehydrolase family....
is triethylenetetramine (TETA). Epoxides are alkylating agents, making many of them highly toxic. Epoxidehydrolase Juliá–Colonna epoxidation Massingill...
from epoxides to less active or inactive dihydroxy-eicosatrienoic acids (diHETrEs) by a widely distributed cellular enzyme, soluble epoxidehydrolase (sEH)...
enzymology, a microsomal epoxidehydrolase (mEH) (EC 3.3.2.9) is an enzyme that catalyzes the hydrolysis reaction between an epoxide and water to form a diol...
epoxidehydrolase (JHEH) is an enzyme that inactivates insect juvenile hormones. This inactivation is accomplished through hydrolysis of the epoxide functional...
Epoxidehydrolase 1 is an enzyme encoded by the EPHX1 gene in humans. Epoxidehydrolase plays an important role in both the activation and detoxification...
this by interfering with the host deubiquitylation system. Cif is an epoxidehydrolase (EH) with unique substrate selectivity. Cif is the first example of...
inhibit microsomal epoxidehydrolase (mEH), the enzyme responsible for the breakdown of the active metabolite carbamazepine-10,11-epoxide into inactive metabolites...
inactivated within seconds or minutes of formation by epoxidehydrolases, particularly soluble epoxidehydrolase, and therefore act locally. CYP1A2 is not regarded...
Epoxide hydrase may refer to: Microsomal epoxidehydrolase Soluble epoxidehydrolaseEpoxidehydrolase This set index page lists enzyme articles associated...
dithiocarbonate. 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxidehydrolase (sEH) inhibitor. It has been shown to lower systemic blood pressure...
participation to form an intermediate epoxide. Hydrolysis of the epoxide leads to a net retention of configuration. Glycoside hydrolases are typically named after...
by epoxide hydrolase (EH) to form BaP-7,8-dihydrodiol. Finally, CYP1A1 catalyses this intermediate to form BaP-7,8-dihydrodiol-9,10-epoxide, which is a...
aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxidehydrolase and aminopeptidase activities), alanyl aminopeptidase...
is subsequently hydrolyzed in vivo to styrene glycol by the enzyme epoxidehydrolase. The US Environmental Protection Agency (EPA) has described styrene...
carrying variant of NAD(P)H:quinone oxidoreductase 1 (NQO1), microsomal epoxidehydrolase (EPHX) and deletion of the glutathione S-transferase T1 (GSTT1) showed...
metabolic inactivation of JH by JH-specific esterase and juvenile hormone epoxidehydrolase. During ecdysis the form of the old cuticle laid down before the next...
(2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxidehydrolase axis in the vasculature and cardiovascular disease". Pharmacological...
2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxidehydrolase axis in the vasculature and cardiovascular disease". Pharmacological...
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