Global InformationJuvenile hormone epoxide hydrolase information
| Juvenile hormone epoxide hydrolase | |||||||
|---|---|---|---|---|---|---|---|
 Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori.[1] | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | JHEH | ||||||
| Alt. symbols | Jheh2 | ||||||
| Entrez | 692686 | ||||||
| PDB | 4QLA | ||||||
| RefSeq (mRNA) | NM_001043736.1 | ||||||
| RefSeq (Prot) | NP_001037201.1 | ||||||
| UniProt | Q6U6J0 | ||||||
| Other data | |||||||
| EC number | 3.3.2.9 | ||||||
| Chromosome | shotgun: 0.63 - 0.65 Mb | ||||||
| |||||||
Juvenile hormone epoxide hydrolase (JHEH) is an enzyme that inactivates insect juvenile hormones. This inactivation is accomplished through hydrolysis of the epoxide functional group contained within these hormones into diols. JHEH is one of two enzymes involved in the termination of signaling properties of the various juvenile hormones.[2] The other is juvenile-hormone esterase, or JHE.[2]
The first observation of activity from JHEH was in Rhodnius prolixus and Schistocerca gregaria. JH esterase was also first observed in this same work.[2]
- ^ Cite error: The named reference
Zhou_2014was invoked but never defined (see the help page). - ^ a b c White AF (February 1972). "Metabolism of the juvenile hormone analogue methyl farnesoate 10, 11-epoxide in two insect species". Life Sciences. 11 (4): 201–210. doi:10.1016/0024-3205(72)90110-5.