Epoxide hydrolase 3 (ABHD9, EH3, EPHX3) is a protein that in humans is encoded by the EPHX3 gene. It is the third defined isozyme in a set of epoxide hydrolase isozymes, the epoxide hydrolases. This set includes the Microsomal epoxide hydrolase (also termed epoxide hydrolase 1, EPHX1, mEH, and EH1); the epoxide hydrolase 2 (also termed soluble epoxide hydrolase, EPHX2, sEH and EH2); and the far less well defined enzymatically, epoxide hydrolase 4 (also termed ABHD7 and EH4). All four enzyme contain an Alpha/beta hydrolase fold suggesting that they have Hydrolysis activity. EH1, EH2, and EH3 have been shown to have such activity in that they add water to epoxides of unsaturated fatty acids to form vicinal cis (see cis-trans isomerism) products; the activity of EH4 has not been reported. The former three EH's differ in subcellular location, tissue expression patterns, substrate preferences, and thereby functions. These functions include limiting the biologically actions of certain fatty acid epoxides, increasing the toxicity of other fatty acid epoxides, and contributing to the metabolism of drugs and other xenobiotics.
^ abcGRCh38: Ensembl release 89: ENSG00000105131 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037577 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
and 21 Related for: Epoxide hydrolase 3 information
Epoxidehydrolases (EHs), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue...
Soluble epoxidehydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxidehydrolase family....
epoxidehydrolase (JHEH) is an enzyme that inactivates insect juvenile hormones. This inactivation is accomplished through hydrolysis of the epoxide functional...
is triethylenetetramine (TETA). Epoxides are alkylating agents, making many of them highly toxic. Epoxidehydrolase Juliá–Colonna epoxidation Massingill...
participation to form an intermediate epoxide. Hydrolysis of the epoxide leads to a net retention of configuration. Glycoside hydrolases are typically named after...
enzymology, a microsomal epoxidehydrolase (mEH) (EC 3.3.2.9) is an enzyme that catalyzes the hydrolysis reaction between an epoxide and water to form a diol...
from epoxides to less active or inactive dihydroxy-eicosatrienoic acids (diHETrEs) by a widely distributed cellular enzyme, soluble epoxidehydrolase (sEH)...
this by interfering with the host deubiquitylation system. Cif is an epoxidehydrolase (EH) with unique substrate selectivity. Cif is the first example of...
2-dihydroxydihydronaphthalene, respectively. The hydration is catalyzed by epoxidehydrolase enzymes. Dehydration of these diols, which is driven by rearomatization...
Epoxidehydrolase 1 is an enzyme encoded by the EPHX1 gene in humans. Epoxidehydrolase plays an important role in both the activation and detoxification...
Zhu Y, Ai D (May 2016). "Soluble epoxidehydrolase: A potential target for metabolic diseases". Journal of Diabetes. 8 (3): 305–313. doi:10.1111/1753-0407...
aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxidehydrolase and aminopeptidase activities), alanyl aminopeptidase...
Multiple-effect humidification, a seawater desalination method Microsomal epoxidehydrolase, an intestinal enzyme National Security Service (Turkey) (Turkish:...
by epoxide hydrolase (EH) to form BaP-7,8-dihydrodiol. Finally, CYP1A1 catalyses this intermediate to form BaP-7,8-dihydrodiol-9,10-epoxide, which is a...
dithiocarbonate. 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxidehydrolase (sEH) inhibitor. It has been shown to lower systemic blood pressure...
by ubiquitous cellular soluble epoxidehydrolase (sEH; also termed epoxidehydrolase 2). Consequently, these epoxides, including EDPs, operate as short-lived...
one hundred times more potent as an inhibitor of liver microsomal epoxidehydrolase. This makes it incompatible with carbamazepine and can affect the...
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