A cartoon depiction of microsomal epoxide hydrolase from Aspergillus niger
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3.3.2.9
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In enzymology, a microsomal epoxide hydrolase (mEH) (EC 3.3.2.9) is an enzyme that catalyzes the hydrolysis reaction between an epoxide and water to form a diol.
Hydrolysis of an epoxide ring
This enzyme plays a role in the uptake of bile salts within the large intestine. It functions as a Na+ dependent transporter. This enzyme participates in metabolism of xenobiotics by cytochrome p450. mEH has been identified as playing a large role in the detoxification and bioactivation of a wide variety of substrates, such as polycyclic aromatic hydrocarbons (PAHs), which are known for their carcinogenic properties.[1]
The human homolog of microsomal epoxide hydrolase is EPHX1 and is located on chromosome 1.[2]
^Kiyohara C, Yoshimasu K, Takayama K, Nakanishi Y (January 2006). "EPHX1 polymorphisms and the risk of lung cancer: a HuGE review". Epidemiology. 17 (1): 89–99. doi:10.1097/01.ede.0000187627.70026.23. PMID 16357600.
^Jackson MR, Craft JA, Burchell B (September 1987). "Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase". Nucleic Acids Research. 15 (17): 7188. doi:10.1093/nar/15.17.7188. PMC 306212. PMID 3502697.
and 23 Related for: Microsomal epoxide hydrolase information
In enzymology, a microsomalepoxidehydrolase (mEH) (EC 3.3.2.9) is an enzyme that catalyzes the hydrolysis reaction between an epoxide and water to form...
through an epoxide hydrolysis reaction to form diol products. Several enzymes possess EH activity. Microsomalepoxidehydrolase (epoxidehydrolase 1, EH1...
Soluble epoxidehydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxidehydrolase family....
both inhibit microsomalepoxidehydrolase (mEH), the enzyme responsible for the breakdown of the active metabolite carbamazepine-10,11-epoxide into inactive...
epoxidehydrolase (JHEH) is an enzyme that inactivates insect juvenile hormones. This inactivation is accomplished through hydrolysis of the epoxide functional...
substance called M3 and an epoxide, M3c. The latter is quickly hydrolyzed to the diol M4 by microsomalepoxidehydrolase (mEH). The enzymes CYP1A1, CYP2C19...
over one hundred times more potent as an inhibitor of liver microsomalepoxidehydrolase. This makes it incompatible with carbamazepine and can affect...
carrying variant of NAD(P)H:quinone oxidoreductase 1 (NQO1), microsomalepoxidehydrolase (EPHX) and deletion of the glutathione S-transferase T1 (GSTT1)...
exogenous chemicals such as polycyclic aromatic hydrocarbons. Microsomalepoxidehydrolase 1 (EPHX1) was first isolated by Watabe and Kanehira from rabbit...
from epoxides to less active or inactive dihydroxy-eicosatrienoic acids (diHETrEs) by a widely distributed cellular enzyme, soluble epoxidehydrolase (sEH)...
Epoxide hydrase may refer to: Microsomalepoxidehydrolase Soluble epoxidehydrolaseEpoxidehydrolase This set index page lists enzyme articles associated...
Multiple-effect humidification, a seawater desalination method Microsomalepoxidehydrolase, an intestinal enzyme National Security Service (Turkey) (Turkish:...
mutagenic metabolites include glutathione S-transferase and microsomalepoxidehydrolase. Mutagens that are not mutagenic by themselves but require biological...
hydrolyzed to glyceramide both spontaneously or enzymatically by microsomalepoxidehydrolase. This too can be excreted through urine. Mice and rats show mutations...
inactivated within seconds or minutes of formation by epoxidehydrolases, particularly soluble epoxidehydrolase, and therefore act locally. CYP2E1 is not regarded...
methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomalepoxidehydrolase-null mice." Toxicology and Applied Pharmacology 205(2): 116-125...
other similarly acting epoxidehydrolases such as microsomalepoxidehydrolase or epoxidehydrolase 2 may prove to hepoxilin hydrolase activity. While the...
inactivated within seconds or minutes of formation by epoxidehydrolases, particularly soluble epoxidehydrolase, and therefore act locally. CYP1A2 is not regarded...
2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxidehydrolase axis in the vasculature and cardiovascular disease". Pharmacological...
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