Top: Normal dynamic of histone acetylation leads to open and closed chromatin genome-wide and changes in gene expression.
Middle: HDAC inhibition repressed the closed-open change favoring an open chromatin state and gene expression.
Bottom: Epigenetic priming general model. Starting with an hypothetical closed chromatin state a priming stimuli sensitizes the chromatin to other stimuli and subsequently increase transcription.
Epigenetic priming (also known as gene priming) is the modification to a cell's epigenome whereby specific chromatin domains within a cell are converted from a closed state to an open state, usually as the result of an external biological trigger or pathway, allowing for DNA access by transcription factors or other modification mechanisms. The action of epigenetic priming for a certain region of DNA dictates how other gene regulation mechanisms will be able to act on the DNA later in the cell’s life. Epigenetic priming has been chiefly investigated in neuroscience and cancer research, as it has been found to play a key role in memory formation within neurons[1] and tumor-suppressor gene activation in cancer treatment[2] respectively.
^Scandura, Joseph M.; Roboz, Gail J.; Moh, Michelle; Morawa, Ewelina; Brenet, Fabienne; Bose, J. Robi; Villegas, Luis; Gergis, Usama S.; Mayer, Sebastian A.; Ippoliti, Cindy M.; Curcio, Tania J. (2011-08-11). "Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML". Blood. 118 (6): 1472–1480. doi:10.1182/blood-2010-11-320093. ISSN 0006-4971. PMC 3156041. PMID 21613261.
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Epigeneticpriming (also known as gene priming) is the modification to a cell's epigenome whereby specific chromatin domains within a cell are converted...
Transgenerational epigenetic inheritance is the transmission of epigenetic markers and modifications from one generation to multiple subsequent generations...
Georgiou A, Leleu M, Fisher AG, Labosky PA, Dillon N (July 2010). "Epigeneticpriming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3...
Xu J; Sun J; Neve RL; Mach RH; Haggarty SJ; Tsai LH. (Jan 2014). "Epigeneticpriming of memory updating during reconsolidation to attenuate remote fear...
specific manipulation of retrieval-extinction on remote memories. The Epigeneticpriming of behavioral memory updating was shown to enable retrieval-extinction...
H3K4me1 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the mono-methylation at the 4th lysine residue...
15 years younger than expected) according to an epigenetic biomarker of tissue age known as epigenetic clock. These findings could explain why the cerebellum...
β-glucan had an increased aerobic glycolysis. Additionally, priming with β-glucan resulted in epigenetic upregulation of genes involved in glycolysis 1 week later...
or retrieval of information by way of procedural memory, or a priming phenomenon. Priming is the process of subliminally arousing specific responses from...
on barrier tissues, or fibroblasts, change their epigenetic state and respond differently after priming insult. At the steady state, unstimulated cells...
across the human genome. DNA methylation plays a significant role in the epigenetic regulation of chromatin structure, which in the last decade has been recognized...
four mechanisms are the storing and recalling, habituation, gene priming or epigenetics, and the biological clock. The ability to respond to environmental...
IL-18, and IL-15 contribute to the development of adaptive NK cells by priming NK cells prior to immune stimulation. Human adaptive NK cells in peripheral...
molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal development, and the molecular basis for neuroplasticity...
episodic memory) and more automatic forms of implicit memory (such as priming). Along with one of his students, Daniel Schacter, Tulving provided several...
to create an epigenetic clock (see article Epigenetic clock). There may be some relationship between the epigenetic clock and epigenetic alterations accumulating...
quiescent stem cells, particularly adult stem cells, also share similar epigenetic patterns. For example, H3K4me3 and H3K27me3, are two major histone methylation...
modulate mimicry behavior. Neuroscientists are suggesting that social priming influences activity and processing in the amPFC, and that this area of...
precede acute myeloid leukemia (AML). As the HUMARA assay is based on the epigenetic state of cells, the underlying genetic determinants of the clonal expansion...
Pomarol-Clotet E, Oh M, Laws KR, McKenna PJ (February 2008). "Semantic priming in schizophrenia: systematic review and meta-analysis". The British Journal...
cells operate as vehicles of inheritance by transferring genetic and epigenetic information from one generation to the next. Male fertility is centered...
chosen larvae royal jelly. The caste differentiation occurs through an epigenetic process; non-heritable factors contributing to gene expression. Queen...
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