S100A7A information

S100A7A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4AQI
Identifiers
Aliases	S100A7A, NICE-2, S100A15, S100A7L1, S100A7f, S100 calcium binding protein A7A, NICE2
External IDs	OMIM: 617427; GeneCards: S100A7A; OMA:S100A7A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,423,222 bp
RNA expression pattern
	Top expressed in
	human penis; ; sperm; ; vulva; ; body of tongue; ; superior surface of tongue; ; thymus; ; sural nerve; ; oral cavity; ; vagina; ; rhombencephalon;
	n/a
	More reference expression data
	n/a
Orthologs
	338324
	n/a
	ENSG00000184330
	n/a
	Q86SG5
	n/a
	NM_176823
	n/a
	NP_789793
	n/a
	Wikidata
View/Edit Human

Protein S100-A7A (S100A7A), also known as koebnerisin, is a protein that in humans is encoded by the S100A7A (alias: S100A15) gene.^[3]

S100 proteins are a diverse calcium-binding family that regulate fundamental cellular and extracellular processes including cell proliferation and differentiation, cell migration, and the antimicrobial host defense as antimicrobial peptides.

Koebnerisin (S100A7A) was first identified upregulated in inflammation-prone psoriatic skin, suggesting involvement in the lesional phenotype of the disease,^[4] Koebner phenomenon. Today, the protein is of further interest because of its role in antimicrobial defence, innate immunity, epidermal cell maturation and epithelial tumorigenesis.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: S100 calcium binding protein A7A".
^ Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, Hengge U, Michel G, Ruzicka T (2003). "Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family". FASEB J. 17 (13): 1969–71. doi:10.1096/fj.03-0148fje. PMID 12923069. S2CID 14817867.
^ Wolf R, Ruzicka T, Yuspa SH (2011). "Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function". Amino Acids. 41 (4): 789–96. doi:10.1007/s00726-010-0666-4. PMC 6410564. PMID 20596736.
^ Zwicker S, Bureik D, Ruzicka T, Wolf R (2012). "[Friend or Foe?--Psoriasin and Koebnerisin: multifunctional defence molecules in skin differentiation, tumorigenesis and inflammation]". Dtsch. Med. Wochenschr. (in German). 137 (10): 491–4. doi:10.1055/s-0031-1299015. PMID 22374659. S2CID 196460709.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184330 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_human-3] "Entrez Gene: S100 calcium binding protein A7A".

[pmid12923069-4] Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, Hengge U, Michel G, Ruzicka T (2003). "Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family". FASEB J. 17 (13): 1969–71. doi:10.1096/fj.03-0148fje. PMID 12923069. S2CID 14817867.

[pmid20596736-5] Wolf R, Ruzicka T, Yuspa SH (2011). "Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function". Amino Acids. 41 (4): 789–96. doi:10.1007/s00726-010-0666-4. PMC 6410564. PMID 20596736.

[pmid22374659-6] Zwicker S, Bureik D, Ruzicka T, Wolf R (2012). "[Friend or Foe?--Psoriasin and Koebnerisin: multifunctional defence molecules in skin differentiation, tumorigenesis and inflammation]". Dtsch. Med. Wochenschr. (in German). 137 (10): 491–4. doi:10.1055/s-0031-1299015. PMID 22374659. S2CID 196460709.

S100A7A information

and 6 Related for: S100A7A information

S100A7A

Stress granule

S100 protein

Epidermal differentiation complex

S100A7

MS100a7a15