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Elongation factor for RNA polymerase II 2 information


ELL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELL2, elongation factor for RNA polymerase II 2, MRCCAT1
External IDsOMIM: 601874; MGI: 2183438; HomoloGene: 8094; GeneCards: ELL2; OMA:ELL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012081

NM_138953

RefSeq (protein)

NP_036213

NP_620403

Location (UCSC)Chr 5: 95.89 – 95.96 MbChr 13: 75.85 – 75.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene. [5]

The encoded protein is a component of the superelongation complex (SEC) and drives immunoglobulin synthesis in plasma cells. Sequence variation in ELL2 has been associated with multiple myeloma and altered immunoglobulin levels.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118985 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001542 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Elongation factor for RNA polymerase II 2". Retrieved 2018-08-24.

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Elongation factor for RNA polymerase II 2

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Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene. The encoded protein is a component of the superelongation...

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RNA polymerase II

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RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA...

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RNA polymerase

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In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that...

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RNA polymerase I

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RNA polymerase 1 (also known as Pol I) is, in higher eukaryotes, the polymerase that only transcribes ribosomal RNA (but not 5S rRNA, which is synthesized...

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RNA polymerase III

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any polymerase) involves three main stages: Initiation, requiring the construction of the RNA polymerase complex on the gene's promoter Elongation, the...

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Negative elongation factor

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(negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase...

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DNA polymerase

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contrast, RNA polymerases synthesize RNA from ribonucleotides from either RNA or DNA.[citation needed] When synthesizing new DNA, DNA polymerase can add...

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RNA polymerase II holoenzyme

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RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins[clarification needed]. RNA polymerase II (also...

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Reverse transcription polymerase chain reaction

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Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called...

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RNA polymerase II subunit B4

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fourth-largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated...

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Transfer RNA

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aminoacyl tRNA synthetases. During protein synthesis, tRNAs with attached amino acids are delivered to the ribosome by proteins called elongation factors, which...

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General transcription factor

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transcription factors are necessary for transcription to occur. In bacteria, transcription initiation requires an RNA polymerase and a single GTF: sigma factor. In...

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Transcription factor II B

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Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)...

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Eukaryotic transcription

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sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex". Proceedings...

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Sigma factor

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initiation factor that enables specific binding of RNA polymerase (RNAP) to gene promoters. It is homologous to archaeal transcription factor B and to eukaryotic...

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Eukaryotic translation elongation factor 1 alpha 1

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of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform...

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Transcription factor

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PMID 12672487. Shilatifard A, Conaway RC, Conaway JW (2003). "The RNA polymerase II elongation complex". Annual Review of Biochemistry. 72: 693–715. doi:10...

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Polymerase chain reaction

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(elongating) DNA strand. The precise time required for elongation depends both on the DNA polymerase used and on the length of the DNA target region to...

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Enhancer RNA

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regions of RNA polymerase II (RNA pol II) binding and non-coding RNA transcription. The level of RNA pol II–enhancer interaction and RNA transcript formation...

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Primary transcript

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modification by transcription factors is another key regulatory factor for transcription by RNA polymerase. In general, factors that lead to histone acetylation...

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Transcription factor II H

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S, Iben S (January 2012). "TFIIH is an elongation factor of RNA polymerase I". Nucleic Acids Research. 40 (2): 650–9. doi:10.1093/nar/gkr746. PMC 3258137...

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Transcription preinitiation complex

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DNA in the RNA polymerase II active site for transcription. The minimal PIC includes RNA polymerase II and six general transcription factors: TFIIA, TFIIB...

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Antisense RNA

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polymerase pausing can also occur which blocks elongation and leads to gene repression. One of the examples is repression of IME4 gene by its asRNA RME2...

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Rabies virus

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and translation. The polymerase is an enzyme and can aid in initiation, elongation, capping, methylation, polyadenylation and RNA polymerization. After...

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Cleavage and polyadenylation specificity factor

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eukaryotes, messenger RNA precursors (pre-mRNA) are transcribed in the nucleus from DNA by the enzyme, RNA polymerase II. The pre-mRNA must undergo post-transcriptional...

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