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Elastin information


ELN
Identifiers
AliasesELN, SVAS, WBS, WS, elastin, ADCL1
External IDsOMIM: 130160; MGI: 95317; GeneCards: ELN; OMA:ELN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007925

RefSeq (protein)

NP_031951

Location (UCSC)Chr 7: 74.03 – 74.07 MbChr 5: 134.73 – 134.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Thick elastic fibers consisting of bundles of elastin in the human lung

Elastin is a protein that in humans is encoded by the ELN gene. Elastin is a key component of the extracellular matrix in gnathostomes (jawed vertebrates).[5] It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting.[6] Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049540 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029675 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mithieux SM, Weiss AS (2005). "Elastin". Advances in Protein Chemistry. 70: 437–461. doi:10.1016/S0065-3233(05)70013-9. ISBN 9780120342709. PMID 15837523.
  6. ^ Vindin H, Mithieux SM, Weiss AS (November 2019). "Elastin architecture". Matrix Biology. 84: 4–16. doi:10.1016/j.matbio.2019.07.005. PMID 31301399. S2CID 196458819.
  7. ^ Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT (April 1993). "The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis". Cell. 73 (1): 159–168. doi:10.1016/0092-8674(93)90168-P. PMID 8096434. S2CID 8274849.

and 28 Related for: Elastin information

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Elastin

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Elastin is a protein that in humans is encoded by the ELN gene. Elastin is a key component of the extracellular matrix in gnathostomes (jawed vertebrates)...

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Extracellular matrix

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tissues contain high amounts of elastins. Elastins are synthesized by fibroblasts and smooth muscle cells. Elastins are highly insoluble, and tropoelastins...

Word Count : 4086

GLB1

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ganglioside substrates and other glycoconjugates. The GLB1 gene also encodes an elastin binding protein. In corn (Zea mays), Glb1 is a gene coding for the storage...

Word Count : 1882

Elastic fiber

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component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts...

Word Count : 1422

Protein

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Most structural proteins are fibrous proteins; for example, collagen and elastin are critical components of connective tissue such as cartilage, and keratin...

Word Count : 11357

Desmosine

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uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries. Desmosine is a component of elastin and cross links...

Word Count : 2016

Connective tissue

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specialized organs such as the cornea.: 161  Elastic fibers, made from elastin and fibrillin, also provide resistance to stretch forces.: 171  They are...

Word Count : 1588

Gnathostomata

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and pelvic fins, arms, legs, wings, etc.), the elastomeric protein of elastin, and a horizontal semicircular canal of the inner ear, along with physiological...

Word Count : 1997

Keratin

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likewise has a high percentage of glycine. The connective tissue protein elastin also has a high percentage of both glycine and alanine. Silk fibroin, considered...

Word Count : 3016

Aneurysm

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results in a decreased activity of the lysyl oxidase enzyme, affecting elastin, a key component in vessel walls. Copper deficiency results in vessel wall...

Word Count : 5367

Vocal cords

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vocal fold. There is a steady increase in the elastin content of the lamina propria as humans age (elastin is a yellow scleroprotein, the essential constituent...

Word Count : 6521

Dinosaur

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antibody binding) demonstrated the presence of proteins such as collagen, elastin, and laminin. Both specimens yielded collagen protein sequences that were...

Word Count : 28217

Breast

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milk glands, the breast is also composed of connective tissues (collagen, elastin), white fat, and the suspensory Cooper's ligaments. Sensation in the breast...

Word Count : 7312

Elastic cartilage

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elastic fiber networks and collagen type II fibers. The principal protein is elastin. Elastic cartilage is histologically similar to hyaline cartilage but contains...

Word Count : 479

Fibril

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Gosilin, J.M.; Aaron, B.B (1981). "Elastin as a Random-network elastomer, a mechanical and optical analysis of single elastin fibers". Biopolymers. 20 (6):...

Word Count : 2559

Jaundice

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has a particularly high affinity for bilirubin deposition due to high elastin content. Slight increases in serum bilirubin can, therefore, be detected...

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Pinguecula

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thought to cause fibroblasts to produce more elastin fibers, which are more twisted than normal elastin fibers and may lead to the degradation of the...

Word Count : 724

Reticular connective tissue

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Ground substance Tissue fluid Fibers Collagen fibers Reticular fibers COL3A1 Elastic fibers Elastin Fibrillin FBN1 FBN2 FBN3 EMILIN1 Elaunin...

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Intracranial aneurysm

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association with the development of intracranial aneurysms, including perlecan, elastin, collagen type 1 A2, endothelial nitric oxide synthase, endothelin receptor...

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Dermis

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composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular...

Word Count : 912

Minoxidil

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in a dose-dependent manner. In hypertensive rats, minoxidil increases elastin level in the mesenteric, abdominal, and renal arteries by a decrease in...

Word Count : 4530

Skin

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with blood vessels and nerves. It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the subcutaneous...

Word Count : 4279

Lung

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the alveolar walls. Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres. Elastin gives the necessary...

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Isodesmosine

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found in elastin. Isodesmosine is an isomeric pyridinium-based amino acid resulting from the condensation of four lysine residues between elastin proteins...

Word Count : 94

Actinic elastosis

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elastosis, also known as solar elastosis, is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, or in the conjunctiva of the...

Word Count : 355

Turtle

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the larynx or glottis that vibrate to produce sound. Other species have elastin-rich vocal cords. Due to their heavy shells, turtles are slow-moving on...

Word Count : 13108

Williams syndrome

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two copies of the elastin gene. Since 98-99% of individuals with WS lack half of the 7q11.23 region of chromosome 7, where the elastin gene is located,...

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Aortic aneurysm

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more common than their thoracic counterpart. One reason for this is that elastin, the principal load-bearing protein present in the wall of the aorta, is...

Word Count : 3430

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