Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Desmosine is an amino acid found uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries.
Desmosine is a component of elastin and cross links with its isomer, isodesmosine, giving elasticity to the tissue. Detection of desmosine in urine, plasma or sputum samples can be a marker for elastin breakdown due to high elastase activity related to certain diseases.[1][2]
^Millipore product catalogue, purified desmosine "Desmosine - Millipore". Archived from the original on 2014-02-24. Retrieved 2014-02-19.
^Ma, S; Turino, G. M.; Lin, Y. Y. (2011). "Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation". Journal of Chromatography B. 879 (21): 1893–8. doi:10.1016/j.jchromb.2011.05.011. PMID 21621489.
Desmosine is an amino acid found uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries. Desmosine is a component...
and allysines can react with other lysine and allysine residues to form desmosine, isodesmosine, and a number of other polyfunctional crosslinks that join...
cysteines involved in the protein's disulfide bonds. Other crosslinks include desmosine. The chiral centers of a polypeptide chain can undergo racemization. Although...
tropoelastin molecules are cross-linked via their lysine residues with desmosine and isodesmosine cross-linking molecules. The enzyme that performs the...
these special cross-links are only found in mature elastin in mammals. Desmosine Miao, M.; Bruce, A.E.E.; Bhanji, T.; Davis, E.C.; Keeley, F.W. (2007)...
C24H40N5O8 (molar mass: 526.603 g/mol, exact mass: 526.2877 u) may refer to: Desmosine Isodesmosine This set index page lists chemical structure articles associated...
collagen (pyridinolines derived from three lysine residues) and in elastin (desmosines derived from four lysine residues) that differ in structure. The importance...
can be seen in addition to the histopathology on electron microscopy. Desmosine has been used to quantify the amount of elastin in lesional skin, which...
interact with several proteins including FBN1, FBN2, tropoelastin and desmosine. It has a relatively non-specific tissue expression pattern, with higher...
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