crystal structure of dnaa domainiv complexed with dnaabox dna
Identifiers
Symbol
Bac_DnaA_C
Pfam
PF08299
Pfam clan
CL0123
InterPro
IPR013159
SCOP2
1j1v / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
DnaA is a protein that activates initiation of DNA replication in bacteria.[1] Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular chromosome called the replicator to start DNA replication.[2] It is a replication initiation factor which promotes the unwinding of DNA at oriC.[1] The DnaA proteins found in all bacteria engage with the DnaA boxes to start chromosomal replication. In addition to the DnaA protein, its concentration, binding to DnaA-boxes, and binding of ATP or ADP, we will cover the regulation of the DnaA gene, the unique characteristics of the DnaA gene expression, promoter strength, and translation efficiency.[2] The onset of the initiation phase of DNA replication is determined by the concentration of DnaA.[1] DnaA accumulates during growth and then triggers the initiation of replication.[1] Replication begins with active DnaA binding to 9-mer (9-bp) repeats upstream of oriC.[1] Binding of DnaA leads to strand separation at the 13-mer repeats.[1] This binding causes the DNA to loop in preparation for melting open by the helicase DnaB.[1]
Bac_DnaA
structure of amppcp-bound dnaa from aquifex aeolicus
Identifiers
Symbol
Bac_DnaA
Pfam
PF00308
Pfam clan
CL0023
InterPro
IPR013317
PROSITE
PDOC00771
SCOP2
1j1v / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
^ abcdefgFoster JB, Slonczewski J (2009). Microbiology: an evolving science. New York: W.W. Norton & Co. ISBN 978-0-393-97857-5.
DnaA is a protein that activates initiation of DNA replication in bacteria. Based on the Replicon Model, a positively active initiator molecule contacts...
DNAA may refer to: DnaA, protein that activates initiation of DNA replication in bacteria Nnamdi Azikiwe International Airport, Abuja, FCT, Nigeria (ICAO:...
Deoxyribonucleic acid (/diːˈɒksɪˌraɪboʊnjuːˌkliːɪk, -ˌkleɪ-/ ; DNA) is a polymer composed of two polynucleotide chains that coil around each other to...
hypothesized that DNA stretching by DnaA bound to the origin promotes strand separation which allows more DnaA to bind to the unwound region. The DnaC helicase...
control origin activity: conserved DNA repeats that are specifically recognized by DnaA (called DnaA-boxes), an AT-rich DNA unwinding element (DUE), and binding...
medium, triggering DNA replication once the cell has reached a specific size. ATP competes with ADP to bind to DnaA, and the DnaA-ATP complex is able...
and dnaC associate near the dnaA bound origin for each of the ssDNA. One dnaB-dnaC complex is oriented in the opposite direction to the other dnaB-dnaC complex...
oriC consists of DNA sequences that are recognised by the DnaA protein, which is highly conserved amongst different bacterial species. DnaA binding to the...
chromosomes Mitochondrial DNA (mtDNA) Chloroplast DNA (cpDNA), and that of other plastids Extrachromosomal circular DNA (eccDNA) Inverse polymerase chain...
2013. "Music Review: DNA – DNA on DNA". "Tom Hull: Grade List: DNA". "DNA: DNA on DNA". Pitchfork. Retrieved 2022-12-08. DNA On DNA at Discogs (list of...
DNA Oyj (DNA) is a Finnish telecommunications company. It was founded in 2000, and refounded in 2007 after a merger. DNA offers cellular phone services...
the complementary strand to that encoding DnaA, a protein that plays a central role in the initiation of DNA replication and hence cellular division. In...
Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food...
DNA profiling (also called DNA fingerprinting and genetic fingerprinting) is the process of determining an individual's deoxyribonucleic acid (DNA) characteristics...
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is...
denaturated proteins, including DnaA, during Heat shock stress. HspQ (YccV like protein domain) is a hemimethylated DNA-binding protein. It has been thought...
cycle. Initially when DnaB binds to dnaA, it is associated with dnaC, a negative regulator. After DnaC dissociates, DnaB binds dnaG. The N-terminal has...
In molecular biology, linker DNA is double-stranded DNA (38-53 base pairs long) in between two nucleosome cores that, in association with histone H1, holds...
of DNA in their genome, called double-stranded DNA (dsDNA) viruses, and those that have one strand of DNA in their genome, called single-stranded DNA (ssDNA)...
isolation of deoxyribonucleic acid (DNA) was done in 1869 by Friedrich Miescher. DNA extraction is the process of isolating DNA from the cells of an organism...
Ishigo-Oka D, Ogasawara N, Moriya S (March 2001). "DnaD protein of Bacillus subtilis interacts with DnaA, the initiator protein of replication". Journal...
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both...
DNA footprinting is a method of investigating the sequence specificity of DNA-binding proteins in vitro. This technique can be used to study protein-DNA...
A DNA database or DNA databank is a database of DNA profiles which can be used in the analysis of genetic diseases, genetic fingerprinting for criminology...
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