CRM197[1] is a non-toxic mutant of diphtheria toxin, currently used as a carrier protein for polysaccharides and haptens to make them immunogenic.[2]
There is some dispute about the toxicity of CRM197, with evidence that it is toxic to yeast cells and some mammalian cell lines.[3]
^Bröker M, Costantino P, DeTora L, McIntosh ED, Rappuoli R (July 2011). "Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications". Biologicals. 39 (4): 195–204. doi:10.1016/j.biologicals.2011.05.004. PMID 21715186.
^"CRM197 Product Details". Reagentproteins.com. Retrieved 3 December 2015.
^Qiao J, Ghani K, Caruso M (March 2008). "Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity". Toxicon. 51 (3): 473–477. doi:10.1016/j.toxicon.2007.09.010. PMID 17988701.
CRM197 is a non-toxic mutant of diphtheria toxin, currently used as a carrier protein for polysaccharides and haptens to make them immunogenic. There is...
(conjugated) through reductive amination to CRM197, a nontoxic recombinant variant of diphtheria toxin. CRM197 is derived from the C7 strain of Corynebacterium...
toxoid CRM197, which is highly immunogenic but non-toxic. This combination provokes a significantly more robust immune response by recruiting CRM197-specific...
and is based in Siena, Italy. Major achievements include development of CRM197 used in Haemophilus influenzae, Neisseria meningitidis, and pneumococcus...
by UK, MCA and Italian Health Branch for Meningitis C polysaccharide and CRM197 carrier protein for conjugated vaccine Menjugate. 2000 – Facility acquired...
needed] Cationized BSA (cBSA)[citation needed] Ovalbumin[citation needed] CRM197 KLH is being tested in a variety of cancer vaccines, including non-Hodgkin's...
vaccine contains 32 micrograms of pneumococcal polysaccharide conjugated with CRM197 (a diphtheria toxin). Another variant is the RNA vaccine, which contains...
et al. (December 2015). "Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human...
Global Information