Verapamil, sold under various trade names,[1] is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.[7] It may also be used for the prevention of migraines and cluster headaches.[8][9] It is given by mouth or by injection into a vein.[7]
Common side effects include headache, low blood pressure, nausea, and constipation.[7] Other side effects include allergic reactions and muscle pains.[10] It is not recommended in people with a slow heart rate or heart failure.[10] It is believed to cause problems for the fetus if used during pregnancy.[2] It is in the non–dihydropyridine calcium channel blocker family of medications.[7]
Verapamil was approved for medical use in the United States in 1981.[7][11] It is on the World Health Organization's List of Essential Medicines.[12][13] Verapamil is available as a generic medication.[7] Long acting formulations exist.[10] In 2021, it was the 196th most commonly prescribed medication in the United States, with more than 2million prescriptions.[14][15]
^ ab"Verapamil". www.drugs.com. Archived from the original on 1 August 2017. Retrieved 14 December 2016.
^ ab"Verapamil Use During Pregnancy". Drugs.com. 18 November 2019. Retrieved 26 March 2020.
^"Securon SR - Summary of Product Characteristics (SmPC)". (emc). 17 May 2017. Retrieved 26 March 2020.
^Cite error: The named reference Calan FDA label was invoked but never defined (see the help page).
^Human Medicines Evaluation Division (14 October 2020). "Active substance(s): verapamil" (PDF). List of nationally authorised medicinal products. European Medicines Agency.
^Schroeder JS, Frishman WH, Parker JD, Angiolillo DJ, Woods C, Scirica BM (2013). "Pharmacologic Options for Treatment of Ischemic Disease". Cardiovascular Therapeutics: A Companion to Braunwald's Heart Disease. Elsevier. pp. 83–130. doi:10.1016/b978-1-4557-0101-8.00007-2. ISBN 978-1-4557-0101-8. The elimination half-life of standard verapamil tablets is usually 3 to 7 hours,...
^ abcdef"Verapamil Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^Merison K, Jacobs H (November 2016). "Diagnosis and Treatment of Childhood Migraine". Current Treatment Options in Neurology. 18 (11): 48. doi:10.1007/s11940-016-0431-4. PMID 27704257. S2CID 28302667.
^ abcWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. hdl:10665/44053. ISBN 9789241547659.
^"Isoptin: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 26 March 2020.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Verapamil - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from...
density in all verapamil-added treatment groups were observed.: 647–656 Gross morphologic features suggested that the combination of verapamil and silicone...
frequency of attacks include steroid injections, galcanezumab, civamide, verapamil, or oral glucocorticoids such as prednisone. Nerve stimulation or surgery...
intracellular side, although the evidence is somewhat mixed. Fendiline Gallopamil Verapamil (Calan, Isoptin) Benzothiazepine calcium channel blockers belong to the...
to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium...
unsuccessful or the PSVT recurs, calcium channel blockers, such as diltiazem or verapamil, are recommended. Adenosine may be safely used during pregnancy. Adenosine...
supraventricular tachycardias (PSVT), diltiazem appears to be as effective as verapamil in treating re-entrant supraventricular tachycardia. Atrial fibrillation...
pressure-rate product and cardiac contractability in comparison with verapamil, a non-dihydropyridine. In turn, following treatment lasting a month,...
papaverine analog, and was first synthesized around the same time as verapamil. It was first registered in 1965. Mebeverine is a generic drug and is...
channel blockers that show different results in use. Fantofarone and verapamil are both calcium channel blockers that behave differently in different...
Norverapamil is a calcium channel blocker. It is the main active metabolite of verapamil. Christiane Pauli-Magnus, Oliver von Richter, Oliver Burk, Anja Ziegler...
and identification of P waves administer AV blockers (e.g., adenosine, verapamil) to identify atrial flutter with 2:1 block Heart sounds should also be...
analog of verapamil. It is used in the treatment of abnormal heart rhythms. Sewing KF, Hannemann H (1983). "Calcium channel antagonists verapamil and gallopamil...
ivabradine, or verapamil. Also, combination of carvedilol with non-dihydropyridine calcium channel blockers, including diltiazem and verapamil, enhances it...
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