Nimodipine, sold under the brand name Nimotop among others, is a calcium channel blocker used in preventing vasospasm secondary to subarachnoid hemorrhage (a form of cerebral hemorrhage). It was originally developed within the calcium channel blocker class as it was used for the treatment of high blood pressure, but is not used for this indication.
It was patented in 1971[3] and approved for medical use in the US in 1988.[4] It was approved for medical use in Germany in 1985.[5]
^"Nimodipine Use During Pregnancy". Drugs.com. March 15, 2019. Retrieved April 11, 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved October 22, 2023.
^GB 1358951, Meyer H, Bossert F, Vater W, Stoepel KN, "New esters, their production, and their medicinal use", published 1974-07-03, assigned to Bayer AG
^"US FDA NDA 018869" (New drug approval from the US FDA). Drugs@FDA.gov Approved Drugs. Food and Drug Administration of the United States (FDA). December 28, 1988. Retrieved April 11, 2019. Nimodipine (...) approved for the treatment of high blood pressure (...)
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 464. ISBN 9783527607495.
Nimodipine, sold under the brand name Nimotop among others, is a calcium channel blocker used in preventing vasospasm secondary to subarachnoid hemorrhage...
until repair can occur. Efforts to treat fevers are also recommended. Nimodipine, a calcium channel blocker, is frequently used to prevent vasospasm. The...
Psychotomimetic effects limit the acceptance of ketamine; however, lamotrigine and nimodipine decrease psychotomimetic effects and can be counteracted also by benzodiazepines...
Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose...
1990). "[Evaluation of the effects of verapamil, flunarizine, diltiazem, nimodipine and placebo in the prevention of hemicrania. A double-blind randomized...
and as such commercialized in for instance nifedipine, amlodipine or nimodipine. The reaction has been demonstrated to proceed in water as reaction solvent...
(Cardene, Carden SR) Nifedipine (Procardia, Adalat) Nilvadipine (Nivadil) Nimodipine (Nimotop) This substance can pass the blood-brain barrier and is used...
ultimately ischemia include L-type calcium channel blockers (notably nimodipine, as well as verapamil, diltiazem, nifedipine) and beta-receptor antagonists...