Dihydrofolate reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder is inherited in the autosomal recessive manner and may present with megaloblastic anemia, cerebral folate deficiency and neurological symptoms of varying type and severity. The patient may have a developmental delay and develop epileptic seizures.
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Dihydrofolatereductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be...
Dihydrofolatereductasedeficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder...
this gene are associated with methylenetetrahydrofolate reductasedeficiency. Complex I deficiency with recessive spastic paraparesis has also been linked...
acid is a form of folic acid that does not require activation by dihydrofolatereductase to be useful to the body. Folinic acid was first made in 1945....
animals but not humans. It works by blocking folate metabolism via dihydrofolatereductase in some bacteria, preventing creation of bacterial DNA and RNA...
therapeutic effects of methotrexate are due to its inhibition of dihydrofolatereductase and thereby reduce the rate de novo purine and pyrimidine synthesis...
steps both catalyzed by the same enzyme, dihydrofolatereductase. Folic acid is first reduced to dihydrofolate and then to tetrahydrofolate. Each step...
acid, in vivo, without relying on dihydrofolatereductase. Folinic acid reduces side effects related to folate deficiency in the patient. Resistance to pyrimethamine...
though at least one study have shown slow and variable activity of dihydrofolatereductase in human liver. A diet rich in natural folate (350 μg/d) can show...
to tetrahydrofolate, a second biologically active vitamer, by dihydrofolatereductase. The liver has a limited capacity to metabolize folic acid into...
Because of its mechanism, tetrahydrobiopterin might interact with dihydrofolatereductase inhibitors like methotrexate and trimethoprim, and NO-enhancing...
found to be deficient. dietary restrictions/supplement: a deficiency in dihydrofolatereductase was treated through oral folinic acid supplements enzyme...
potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolatereductase. Since many oxidoreductases use NAD+ and NADH as substrates...
protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolatereductase (DHFR). Methotrexate Pemetrexed Raltitrexed Pralatrexate Many are...
Cerebral folate deficiency is a condition in which concentrations of 5-methyltetrahydrofolate are low in the brain as measured in the cerebral spinal fluid...
from a deficiency in adenosine deaminase activity, which causes a buildup of dATP. These dATP molecules then inhibit ribonucleotide reductase, which prevents...
dihydrofolatereductase, which catalyzes the reduction of dihydrofolate to tetrahydrofolate. The similarity between the structures of dihydrofolate and...
blocking the metabolism of folic acid (it is an inhibitor of the dihydrofolatereductase). Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase...
increased risk of future cancer and pancreatitis. Those with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects....
originally was first identified in a study focusing on replication of dihydrofolatereductase gene (dhfr) in Chinese hamsters, with it initiating near stable...
or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency. Those with partial or complete DPD deficiency have a significantly...
intrinsic resistance conferred by MGMT deficiency (MGMTd) and 2) intrinsic or acquired resistance through MMR deficiency (MMRd). The MGMT enzyme is the first...
or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency. Those with partial or complete DPD deficiency have a significantly...
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