Not to be confused with D-amino acid oxidase or D-aspartate oxidase.
Diamine oxidase
Diamine oxidase dimer, Human
Identifiers
EC no.
1.4.3.22
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Diamine oxidase (DAO), also known "amine oxidase, copper-containing, 1" (AOC1), formerly called histaminase,[1] is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation, and inactivation of histamine and other polyamines such as putrescine or spermidine. The enzyme belongs to the amine oxidase (copper-containing) (AOC) family of amine oxidase enzymes.
The enzyme is expressed in bilateria, a biological group of animals. The enzyme is encoded by the AOC1 gene. This gene is highly conserved across the bilateria group which includes mammals, birds, reptiles, fish and insects, to name a few.
^Wolvekamp MC, de Bruin RW (1994). "Diamine oxidase: an overview of historical, biochemical and functional aspects". Digestive Diseases. 12 (1): 2–14. doi:10.1159/000171432. PMID 8200121.
Diamineoxidase (DAO), also known "amine oxidase, copper-containing, 1" (AOC1), formerly called histaminase, is an enzyme (EC 1.4.3.22) involved in the...
its primary degradative enzymes, histamine-N-methyltransferase or diamineoxidase. In the central nervous system, histamine released into the synapses...
Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group...
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A)...
reduced activity or levels of the enzymes that metabolize histamine: diamineoxidase (DAO) and histamine N-methyltransferase (HNMT). Still, the exact prevalence...
Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. This gene is one of two neighboring...
cytochrome c oxidase, which is complex IV in the mitochondrial electron transport chain, ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These...
The oxidase test is used to determine whether an organism possesses the cytochrome c oxidase enzyme. The test is used as an aid for the differentiation...
that its effect is due to the inhibition of diamineoxidase, coupled with a weak inhibition of monoamine oxidase A. Selikoff and Robitzek also experimented...
and trace amine-transmitters may worsen in combination with monoamine oxidase inhibitors. Shen H, Kannari K, Yamato H, Arai A, Matsunaga M (March 2003)...
the enteric nervous system, brain, and elsewhere by the actions of diamineoxidase and aldehyde dehydrogenase 1a1. Several truncated transcripts and polypeptides...
are the source of most serotonin in the stomach in rodents. Allergy Diamineoxidase Food intolerance Granulocyte Histamine intolerance Histamine N-methyltransferase...
under development as a drug. Pimagedine functions as an inhibitor of diamineoxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation...
Brew OB, Sullivan MH (September 2001). "Localisation of mRNAs for diamineoxidase and histamine receptors H1 and H2, at the feto-maternal interface of...
product, which then undergoes oxidative deamination by the action of diamineoxidase to yield the aminoaldehyde. Schiff base formation confirms the biosynthesis...
neurotransmitter). GABA can also be synthesized from putrescine by diamineoxidase and aldehyde dehydrogenase. Historically it was thought that exogenous...
namely harmaline and harmine, is a reversible inhibitor of monoamine oxidase A (RIMA), but it also inhibits the reuptake of serotonin. THH contributes...
chloroethylamine into chloroacetaldehyde, and inhibits multiple amine oxidase activities, preventing the formation of CAA. The dosing of methylene blue...
4-naphthoquinone (sometimes called 2,3,6-TQ and TMN) which is a reversible monoamine oxidase inhibitor of type A and B with a binding affinity somewhat similar to that...
formation of methyl radicals which lead to liver necrosis. Inhibition of diamineoxidase (histaminase) elevates histamine levels, resulting in headaches, nausea...
histamine from mast cells and inhibits its degradations by inhibiting diamineoxidase. Though histamine is used by the body to mediate alcohol-induced gastric...
causes oxidative stress leading to methemoglobinemia. Inhibition of diamineoxidase (histaminase) elevates histamine levels resulting in headaches, nausea...
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