Opioid painkiller medication
Desmetramadol Other names O -Desmethyltramadol; O -DSMT; OmnitramMetabolism CYP3A4 and CYP2B6[1] Elimination half-life 6-8 hours
3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol
CAS Number 80456-81-1 N PubChem CID ChemSpider 115703 Y UNII ChEMBL ChEMBL1400 N CompTox Dashboard (EPA ) DTXSID40894102 Formula C 15 H 23 N O 2 Molar mass 249.354 g·mol−1 3D model (JSmol)
OC2(c1cc(O)ccc1)CCCCC2CN(C)C
InChI=1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3
Y Key:UWJUQVWARXYRCG-UHFFFAOYSA-N
Y
N Y (what is this?) (verify)
Desmetramadol (INN Tooltip International Nonproprietary Name ), also known as O -desmethyltramadol (O -DSMT ), is an opioid analgesic and the main active metabolite of tramadol.[2] Tramadol is demethylated by the liver enzyme CYP2D6[3] to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 will tend to have reduced analgesic effects from tramadol. Because desmetramadol itself does not need to be metabolized to induce an analgesic effect, it can be used in individuals with low CYP2D6 activity unlike tramadol.
^ Tramadol Pharmacokinetics, PharmGKB
^ Sevcik J, Nieber K, Driessen B, Illes P (September 1993). "Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones". British Journal of Pharmacology . 110 (1): 169–76. doi:10.1111/j.1476-5381.1993.tb13788.x. PMC 2175982 . PMID 8220877.
^ Borlak J, Hermann R, Erb K, Thum T (November 2003). "A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol". Metabolism . 52 (11): 1439–43. doi:10.1016/s0026-0495(03)00256-7. PMID 14624403.
Last Update: 2024-03-15T23:27:34Z
Desmetramadol (INNTooltip International Nonproprietary Name), also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite...
Word Count : 1410
Last Update: 2024-05-27T19:57:22Z
breastfeeding. Tramadol is converted in the liver to O-desmethyltramadol (desmetramadol ), an opioid with a stronger affinity for the μ-opioid receptor. Tramadol...
Word Count : 9171
Last Update: 2024-06-24T10:58:50Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 17936
Last Update: 2024-06-15T19:47:59Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 11954
Last Update: 2024-06-23T02:28:52Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 16053
Last Update: 2024-06-10T11:39:52Z
ziprasidone, zotepine) Captodiame CEPC Cinanserin Cyproheptadine Deramciclane Desmetramadol Dotarizine Eltoprazine Ergolines (e.g., amesergide, bromocriptine, LY-53857...
Word Count : 15793
Last Update: 2024-06-25T04:19:40Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 13712
Last Update: 2024-06-17T04:17:03Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 11462
Last Update: 2024-06-15T16:22:11Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 11401
Last Update: 2023-01-30T22:01:52Z
also been sold in its own right since late 2019. 3-HO-PCP 4-Keto-PCP Desmetramadol Deoxymethoxetamine Fluorexetamine Menzies EL, Hudson SC, Dargan PI,...
Word Count : 191
Last Update: 2024-06-10T07:05:31Z
[D-Ala2]Deltorphin II >1,000 3.3 >1,000 Dermorphin 0.33 >1,000 >1,000 (+)-Desmetramadol (O-DSMT) 17 690 1,800 Dextropropoxyphene 34.5 380 1,220 Dezocine 3.6...
Word Count : 19665
Last Update: 2024-04-05T05:21:37Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 1711
Last Update: 2024-06-20T06:31:30Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 4004
Last Update: 2024-06-22T09:02:24Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 7675
Last Update: 2024-06-24T05:08:55Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 4104
Last Update: 2024-05-28T20:21:12Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 8072
Last Update: 2024-06-10T05:46:40Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 10526
Last Update: 2024-05-11T17:46:16Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 6082
Last Update: 2024-05-25T08:40:29Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 5382
Last Update: 2024-06-20T11:42:02Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 6533
Last Update: 2024-06-24T15:38:40Z
ziprasidone, zotepine) Captodiame CEPC Cinanserin Cyproheptadine Deramciclane Desmetramadol Dotarizine Eltoprazine Ergolines (e.g., amesergide, bromocriptine, LY-53857...
Word Count : 14646
Last Update: 2024-06-10T21:45:31Z
ziprasidone, zotepine) Captodiame CEPC Cinanserin Cyproheptadine Deramciclane Desmetramadol Dotarizine Eltoprazine Ergolines (e.g., amesergide, bromocriptine, LY-53857...
Word Count : 9106
Last Update: 2024-06-21T08:11:17Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 10453
Last Update: 2024-06-12T04:17:49Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 15614
Last Update: 2024-06-24T22:15:33Z
Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene)...
Word Count : 2039
Last Update: 2024-06-17T01:59:39Z
Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)...
Word Count : 1689