oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
signaling receptor binding
isocitrate dehydrogenase (NADP+) activity
oxidoreductase activity
NAD binding
isocitrate dehydrogenase activity
NADP binding
metal ion binding
(R)-2-hydroxyglutarate dehydrogenase activity
cadherin binding
identical protein binding
Cellular component
peroxisome
cytosol
extracellular exosome
peroxisomal matrix
cytoplasm
mitochondrion
extracellular region
secretory granule lumen
tertiary granule lumen
ficolin-1-rich granule lumen
Biological process
female gonad development
NADPH regeneration
response to oxidative stress
response to organic cyclic compound
response to steroid hormone
2-oxoglutarate metabolic process
regulation of phospholipid catabolic process
isocitrate metabolic process
glyoxylate cycle
tricarboxylic acid cycle
regulation of phospholipid biosynthetic process
glutathione metabolic process
neutrophil degranulation
protein targeting to peroxisome
NADP metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3417
15926
Ensembl
ENSG00000138413
ENSMUSG00000025950
UniProt
O75874
O88844
RefSeq (mRNA)
NM_005896 NM_001282386 NM_001282387
NM_001111320 NM_010497
RefSeq (protein)
NP_001269315 NP_001269316 NP_005887
NP_001104790 NP_034627
Location (UCSC)
Chr 2: 208.24 – 208.27 Mb
Chr 1: 65.2 – 65.23 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD+ as the electron acceptor and the other NADP+. Five isocitrate dehydrogenases have been reported: three NAD+-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP+-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP+-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2,4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013][5]
^ abcGRCh38: Ensembl release 89: ENSG00000138413 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025950 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid...
dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation...
glioma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), which are mutated in several forms...
mutations (mostly in IDH1) occurs in about 80% of low grade gliomas and secondary high-grade gliomas. Wang et al. pointed out that IDH1 and IDH2 mutant cells...
Because the incidence of IDH1/2 mutations increases as the disease malignancy increases, these findings together suggest that IDH1/2 mutations are important...
acute myeloid leukemia with a susceptible IDH1 mutation. Olutasidenib is an isocitrate dehydrogenase-1 (IDH1) inhibitor. It is taken by mouth. The most...
therapy. Astrocytomas carry a mutation in IDH1 or IDH2, whereas this mutation is not present in glioblastoma. Thus, IDH1 and IDH2 mutations are a useful tool...
cholangiocarcinoma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1), which is mutated in several forms of cancer. Ivosidenib is an isocitrate...
bone neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment...
tumors. IDH1 catalyzes this reaction in the cytoplasm, while IDH2 catalyzes this reaction in mitochondria. Mutations of IDH2 are more common than IDH1 mutations...
these tumors become more dependent on glutamate due to mutations in the gene IDH1. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate...
mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, D-2-hydroxyglutarate...
advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test. Durvalumab, (Imfinzi) is an...
tissue types with IDH1/2 mutations show improved responses to radiation and chemotherapy. Inhibitors of the neomorphic activity of mutant IDH1 and IDH2 are...
the presence or absence of a targeted protein via staining. Mutations in IDH1 and IDH2 genes are commonly found in low-grade gliomas Loss of both IDH genes...
tumors belong to the proneural subgroup and were tightly associated with IDH1 somatic mutations. TCGA reported on mRNA expression, microRNA expression...
"Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted", and requires the presence of IDH1 or IDH2 mutations and the codeletion of chromosome 1p and 19q arms. Interestingly...
dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1". "Tomatillo: A Potential Vegetable Crop for Louisiana". Jiménez-Santana...
Fitim; Pollock, Robin; O'Donnell, Paul; Grigoriadis, Anita (Jul 2011). "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central...
unwanted mutations were introduced into the cell line. The cell line carries an IDH1 mutation and an activated N-ras oncogene. Rasheed, Suraiya; Nelson-Rees,...
with tumors harboring additional activating molecular alterations (e.g., IDH1/2 mutations, FGFR mutations) or with a known or suspected diagnosis of neurofibromatosis...
spectroscopy (MRS) has been shown to be a noninvasive procedure. The presence of IDH1 or IDH2 mutations was linked to the detection of this oncometabolite 100...
the TCA cycle of cancer cells by inhibiting isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), respectively. Ivosidenib is specific...
M, Sill M, Bender S, Kool M.... N. Jablo. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer...
apparent. Maffucci syndrome is most commonly caused by mutations in the IDH1 or IDH2 gene. In Ollier's disease, isolated enchondromas are present without...
initial treatment with for example BCL2-inhibitors, FLT3-inhibitors, or IDH1/2-inhibitors, may kill leukemic cells. However, pre-leukemic clones may survive...
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