In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in C. elegans and mammalian proteins.[1] In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides.[2] These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription.[3][4]
The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences .[2][5][6] The NMR analysis of the DSX DM domain [6] revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.
^Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.
^ abErdman SE, Chen HJ, Burtis KC (December 1996). "Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins". Genetics. 144 (4): 1639–52. doi:10.1093/genetics/144.4.1639. PMC 1207715. PMID 8978051.
^Burtis KC, Coschigano KT, Baker BS, Wensink PC (September 1991). "The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer". EMBO J. 10 (9): 2577–82. doi:10.1002/j.1460-2075.1991.tb07798.x. PMC 452955. PMID 1907913.
^Shen MM, Hodgkin J (September 1988). "mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans". Cell. 54 (7): 1019–31. doi:10.1016/0092-8674(88)90117-1. PMID 3046751. S2CID 1386352.
^Yi W, Zarkower D (February 1999). "Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms". Development. 126 (5): 873–81. doi:10.1242/dev.126.5.873. PMID 9927589.
^ abZhu L, Wilken J, Phillips NB, Narendra U, Chan G, Stratton SM, Kent SB, Weiss MA (July 2000). "Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers". Genes Dev. 14 (14): 1750–64. doi:10.1101/gad.14.14.1750. PMC 316782. PMID 10898790.
In molecular biology the DMdomain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in C. elegans...
Look up DM or dm in Wiktionary, the free dictionary. DM, Dm, dm, or D.M. may stand for: DM Yadav Doctor of Management, an academic management degree Doctor...
Examples include—ORRES, --STRESC, and—STRESN. Many of the values in the DMdomain are also classified as Result Qualifiers. Synonym Qualifiers specify an...
In the Internet, a domain name is a string that identifies a realm of administrative autonomy, authority or control. Domain names are often used to identify...
family, having in common a zinc finger-like DNA-binding motif (DMdomain). The DMdomain is an ancient, conserved component of the vertebrate sex-determining...
An internationalized domain name (IDN) is an Internet domain name that contains at least one label displayed in software applications, in whole or in...
processes can be classified into generic and domain-specific ones. Generic standard processes (e.g., CRISP-DM, ASUM-DM, KDD, SEMMA, or Team Data Science Process)...
Shuichi; Shimizu, Nobuyoshi; Hori, Hiroshi (May 2002). "DMY is a Y-specific DM-domain gene required for male development in the medaka fish". Nature. 417 (6888):...
distributed free of charge as public domain software. It was also donationware as the author asked for donations of 20 DM, offering as incentive the source...
Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, et al. (October 2016). "Formation of new chromatin domains determines pathogenicity...
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates...
PIM Dense Mode (PIM-DM) uses dense multicast routing. It implicitly builds shortest-path trees by flooding multicast traffic domain wide, and then pruning...
every pair of elements x, y of a GCD domain R, a GCD d of x and y and an LCM m of x and y can be chosen such that dm = xy, or stated differently, if x and...
USS Tracy (DD-214/DM-19) was a Clemson-class destroyer in the United States Navy during World War II. She was the only ship named for Secretary of the...
and Koonin using iterative sequence searches. Chipman DM, Shaanan B (December 2001). "The ACT domain family". Current Opinion in Structural Biology. 11 (6):...
USS Lindsey (DD-771/DM-32/MMD-32) was a Robert H. Smith-class destroyer minelayer in the United States Navy during World War II. She was named for Eugene...
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