Crystal structure of E. coli aspartokinase iii in complex with aspartate and adp (r-state)
Identifiers
Symbol
ACT
Pfam
PF01842
Pfam clan
CL0070
InterPro
IPR002912
SCOP2
1psd / SCOPe / SUPFAM
CDD
cd02116
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, the ACT domain is a protein domain that is found in a variety of proteins involved in metabolism. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. The ACT domain is named after three of the proteins that contain it: aspartate kinase, chorismate mutase and TyrA. The archetypical ACT domain is the C-terminal regulatory domain of 3-phosphoglycerate dehydrogenase (3PGDH), which folds with a ferredoxin-like topology. A pair of ACT domains form an eight-stranded antiparallel sheet with two molecules of allosteric inhibitor serine bound in the interface. Biochemical exploration of a few other proteins containing ACT domains supports the suggestions that these domains contain the archetypical ACT structure.[1]
The ACT domain was discovered by Aravind and Koonin using iterative sequence searches.[2]
^Chipman DM, Shaanan B (December 2001). "The ACT domain family". Current Opinion in Structural Biology. 11 (6): 694–700. doi:10.1016/S0959-440X(01)00272-X. PMID 11751050.
^Aravind L, Koonin EV (April 1999). "Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches". Journal of Molecular Biology. 287 (5): 1023–40. doi:10.1006/jmbi.1999.2653. PMID 10222208.
molecular biology, the ACTdomain is a protein domain that is found in a variety of proteins involved in metabolism. ACTdomains are linked to a wide range...
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