cyclin-dependent protein kinase holoenzyme complex
Biological process
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of mRNA polyadenylation
regulation of transcription, DNA-templated
transcription elongation from RNA polymerase II promoter
transcription by RNA polymerase II
cell division
protein phosphorylation
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of viral transcription
cell cycle
positive regulation of transcription by RNA polymerase II
viral process
transcription, DNA-templated
snRNA transcription by RNA polymerase II
regulation of transcription by RNA polymerase II
positive regulation of DNA-templated transcription, elongation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
904
12455
Ensembl
ENSG00000129315
ENSMUSG00000011960
UniProt
O60563
Q9QWV9
RefSeq (mRNA)
NM_001240 NM_001277842
NM_009833 NM_001368702
RefSeq (protein)
NP_001231 NP_001264771
NP_033963 NP_001355631
Location (UCSC)
Chr 12: 48.69 – 48.72 Mb
Chr 15: 98.44 – 98.47 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000129315 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000011960 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wei P, Garber ME, Fang SM, Fischer WH, Jones KA (March 1998). "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA". Cell. 92 (4): 451–62. doi:10.1016/S0092-8674(00)80939-3. PMID 9491887. S2CID 16395032.
^Peng J, Zhu Y, Milton JT, Price DH (April 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581. PMID 9499409.
Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose...
nerve 1, a nerve emerging from the vertebrae CyclinT1, a human gene GalNAc-T1, a human gene Ribonuclease T1, a fungal endonuclease TNM staging system,...
involved in the phosphorylation and regulation of the RPB1 CTD is cyclinT1 (CCNT1). CyclinT1 tightly associates and forms a complex with CDK9 kinase, both...
D (July 2011). "Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclinT1 interaction in Nef-dependent...
notch receptor signaling. Granulin has also been shown to interact with CyclinT1 and TRIB3. Although progranulin expression increases as cells mature,...
protein has been shown to interact with: ANKRD2, CREB-binding protein, CyclinT1, Death associated protein 6, GATA2, HDAC1, HDAC3, HHEX, MAPK11, MYB, Mdm2...
without c-Myc. Myc has been shown to interact with: ACTL6A BRCA1 Bcl-2 CyclinT1 CHD8 DNMT3A EP400 GTF2I HTATIP let-7 MAPK1 MAPK8 MAX MLH1 MYCBP2 MYCBP...
Zhou Q (November 2001). "The 7SK small nuclear RNA inhibits the CDK9/cyclinT1 kinase to control transcription". Nature. 414 (6861): 317–22. Bibcode:2001Natur...
human immunodeficiency virus replication are facilitated by human cyclinT1 but not cyclins T2a or T2b". Virology. 255 (1): 182–9. doi:10.1006/viro.1998.9589...
P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclinT1 complexes". Molecular and Cellular Biology. 28 (11): 3623–38...
is encoded by the HEXIM1 gene. HEXIM1 has been shown to interact with CyclinT1 and Cdk9 GRCh38: Ensembl release 89: ENSG00000186834 – Ensembl, May 2017...
itself. Pur-alpha also binds CyclinT1, a regulatory partner of Cdk9 protein kinase, necessary for Tat activity. CyclinT1/Cdk9 phosphorylates a region...
P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclinT1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome"...
between the trans-activation response RNA-binding protein, TRBP2, and cyclinT1 on HIV type 1 expression and viral production in murine cells". AIDS Research...
"Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclinT1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription"...
P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclinT1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem...
"Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclinT1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription"...
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