POLR2B information

POLR2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2B, POL2RB, RPB2, hRPB140, hsRPB2, polymerase (RNA) II subunit B, RNA polymerase II subunit B
External IDs	OMIM: 180661; MGI: 2388280; HomoloGene: 722; GeneCards: POLR2B; OMA:POLR2B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	57,031,158 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,497,171 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; endothelial cell; ; middle temporal gyrus; ; tibia; ; human penis; ; Brodmann area 23; ; parietal pleura; ; Achilles tendon; ; urethra; ; synovial joint;
	Top expressed in
	saccule; ; otic placode; ; primitive streak; ; hair follicle; ; ciliary body; ; ureter; ; medullary collecting duct; ; retinal pigment epithelium; ; trigeminal ganglion; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; ribonucleoside binding; RNA polymerase II activity; chromatin binding; metal ion binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; RNA binding;
Cellular component	membrane; RNA polymerase II, core complex; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; somatic stem cell population maintenance; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; positive regulation of viral transcription; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; transcription, DNA-templated; RNA metabolic process; regulation of gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologs
	5431
	231329
	ENSG00000047315
	ENSMUSG00000029250
	P30876
	Q8CFI7
	NM_001303269; NM_000938; NM_001303268
	NM_153798
	NP_000929; NP_001290197; NP_001290198
	NP_722493
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.^[5]^[6]

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000047315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029250 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Acker J, Wintzerith M, Vigneron M, et al. (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol. 226 (4): 1295–9. doi:10.1016/0022-2836(92)91071-V. PMID 1518060.
^ Acker J, Mattei MG, Wintzerith M, et al. (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
^ "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000047315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029250 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1518060-5] Acker J, Wintzerith M, Vigneron M, et al. (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol. 226 (4): 1295–9. doi:10.1016/0022-2836(92)91071-V. PMID 1518060.

[pmid8034326-6] Acker J, Mattei MG, Wintzerith M, et al. (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.

[7] "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa".

POLR2B information

and 8 Related for: POLR2B information

POLR2B

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