Human Immunodeficiency Virus (HIV) has the capability to enter a latent stage of infection where it exists as a dormant provirus in CD4+ T-cells. Most latently infected cells are resting memory T cells,[1] however a small fraction of latently infected cells isolated from HIV patients are naive CD4 T cells.[2]
^Tyagi, Mudit; Pearson, Richard John; Karn, Jonathan (July 2010). "Establishment of HIV Latency in Primary CD4 + Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction". Journal of Virology. 84 (13): 6425–6437. doi:10.1128/JVI.01519-09. ISSN 0022-538X. PMC 2903277. PMID 20410271.
^Brenchley, Jason M.; Hill, Brenna J.; Ambrozak, David R.; Price, David A.; Guenaga, Francisco J.; Casazza, Joseph P.; Kuruppu, Janaki; Yazdani, Javaidia; Migueles, Stephen A.; Connors, Mark; Roederer, Mario; Douek, Daniel C.; Koup, Richard A. (February 2004). "T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis". Journal of Virology. 78 (3): 1160–1168. doi:10.1128/JVI.78.3.1160-1168.2004. ISSN 0022-538X. PMC 321406. PMID 14722271.
have correlated latency with the relaxation of activated T cells to a resting-memory state. Latency was initially thought to be due to HIV proviral genome...
Virus latency (or viral latency) is the ability of a pathogenic virus to lie dormant (latent) within a cell, denoted as the lysogenic part of the viral...
latency, an infection is subclinical. With respect to viral infections, in incubation the virus is replicating. This is in contrast to viral latency,...
chronic condition in which progression to AIDS is increasingly rare. HIVlatency, and the consequent viral reservoir in CD4+ T cells, dendritic cells...
systematic high-throughput screening as a potential HIVlatency reversing agent (LRA). Reactivation of latentHIV infection in patients is part of an investigational...
Kim YK et al., Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency. EMBO J. 2006 Aug 9;25(15):3596-604 Blau...
ISBN 978-0-323-95389-4, retrieved 2023-03-06 Siliciano, Robert F. (2011). "HIVLatency". Cold Spring Harbor Perspectives in Medicine. 1 (1). Cold Spring Harbor...
unspliced HIV RNA, an early product of viral transcription, in people receiving antiretroviral drugs. Lewin's laboratory has developed models of HIVlatency which...
virologist and quantitative biologist. He is credited with discovering the HIV virus latency circuit, which provided the first experimental evidence that stochastic...
earlier phase II study. Vorinostat is being investigated as a potential HIVlatency reversing agent (LRA) as part of an investigational therapeutic strategy...
Delaney Collaboratory to study HIVlatency. Studying the "accelerated aging" effects associated with HIV/AIDS. Studying how HIV integrates and replicates within...
diabetic patients. Persons with HIV and latent tuberculosis have a 10% chance of developing active tuberculosis every year. "HIV infection is the greatest known...
speak, or sneeze. People with latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis...
transcription elongation is implicated in cancer, neurodegeneration, HIVlatency etc. The eukaryotic core RNA polymerase II was first purified using transcription...
disease in immunocompromised patients Clinical latency Virus latency "About HIV/AIDS | HIV Basics | HIV/AIDS". U.S. Centers for Disease Control and Prevention...
in clinical latency, the next stage of the infection. The asymptomatic or clinical latency phase is marked by slow replication of the HIV virus, followed...
The co-epidemic of tuberculosis (TB) and human immunodeficiency virus (HIV) is one of the major global health challenges in the present time. The World...
HIV superinfection (also called HIV reinfection or SuperAIDS) is a condition in which a person with an established human immunodeficiency virus infection...
infected with HIV or treat HIV-infected individuals. It is thought that an HIV vaccine could either induce an immune response against HIV (active vaccination...
sores, to remain in a dormant state within the human body. This is called latency and is a characteristic of the herpes viruses, including Epstein–Barr virus...
late lytic, are distinct from the latency stage. In the case of HSV-1, no protein products are detected during latency, whereas they are detected during...
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