microglial cell activation involved in immune response
lysosome organization
lysosomal transport
lysosomal lumen acidification
positive regulation of endothelial cell migration
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of axon regeneration
positive regulation of epithelial cell proliferation
protein stabilization
negative regulation of respiratory burst involved in inflammatory response
positive regulation of inflammatory response to wounding
positive regulation of defense response to bacterium
negative regulation of neutrophil activation
positive regulation of protein folding
negative regulation of microglial cell activation
positive regulation of aspartic-type peptidase activity
positive regulation of lysosome organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2896
14824
Ensembl
ENSG00000030582
ENSMUSG00000034708
UniProt
P28799
P28798
RefSeq (mRNA)
NM_001012479 NM_002087
NM_008175
RefSeq (protein)
NP_002078
NP_032201
Location (UCSC)
Chr 17: 44.35 – 44.35 Mb
Chr 11: 102.32 – 102.33 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Granulin
The solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human granulin a
Identifiers
Symbol
Granulin
Pfam
PF00396
InterPro
IPR000118
PROSITE
PDOC00634
SCOP2
1pcn / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Granulin is a protein that in humans is encoded by the GRN gene.[5][6][7] Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long and 68.5 kDa protein.[8] While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis. The 2006 discovery of the GRN mutation in a population of patients with frontotemporal dementia has spurred much research in uncovering the function and involvement in disease of progranulin in the body. While there is a growing body of research on progranulin's role in the body, studies on specific granulin residues are still limited.
^ abcGRCh38: Ensembl release 89: ENSG00000030582 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000034708 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bhandari V, Bateman A (October 1992). "Structure and chromosomal location of the human granulin gene". Biochemical and Biophysical Research Communications. 188 (1): 57–63. doi:10.1016/0006-291X(92)92349-3. PMID 1417868.
^Zhang H, Serrero G (November 1998). "Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)". Proceedings of the National Academy of Sciences of the United States of America. 95 (24): 14202–14207. Bibcode:1998PNAS...9514202Z. doi:10.1073/pnas.95.24.14202. PMC 24351. PMID 9826678.
^"Entrez Gene: GRN granulin".
^Eriksen JL, Mackenzie IR (January 2008). "Progranulin: normal function and role in neurodegeneration". Journal of Neurochemistry. 104 (2): 287–297. doi:10.1111/j.1471-4159.2007.04968.x. PMID 17953663. S2CID 43261477.
Granulin is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long...
established as a major genetic contribution of FTLD, although defects in the granulin (GRN) and microtubule-associated proteins (MAPs) are also associated with...
inclusion cases, including 89 individuals carrying pathogenic mutations in the granulin (GRN) gene, a known cause of familial FTLD-GRN identified a single nucleotide...
network Global Recordings Network, US Christian network Goods Received Note Granulin Grenada, IOC and UNDP country code Guarani dialects, ISO-639 code This...
primary progressive aphasia structural lesion suggestive of focal cause granulin mutation or reduced plasma progranulin levels TDP-43 or fused in sarcoma...
Occlusion-derived virus (ODV) is present in a protein matrix (polyhedrin or granulin) and is responsible for the primary infection of the host, while the budded...
primary progressive aphasia structural lesion suggestive of focal cause granulin mutation or reduced plasma progranulin levels TDP-43 or fused in sarcoma...
protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Archives of...
been shown to interact with the following: Aryl hydrocarbon receptor CDK9 Granulin HEXIM1 Myc NUFIP1 Promyelocytic leukemia protein GRCh38: Ensembl release...
protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Arch. Biochem...
populations. The human progranulin protein (PGRN), encoded by the human granulin gene (GRN), is co-expressed with and interacts with PLD3 accumulated on...
protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Archives of...
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