237 to 243 °C (459 to 469 °F; 510 to 516 K) (decomposes)
Pharmacology
ATC code
D08AJ02 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
Cetrimonium bromide, also known with the abbreviation CTAB, is a quaternary ammonium surfactant with a condensed structural formula [(C16H33)N(CH3)3]Br.
It is one of the components of the topical antiseptic cetrimide.[1] The cetrimonium (hexadecyltrimethylammonium) cation is an effective antiseptic agent against bacteria and fungi. It is also one of the main components of some buffers for the extraction of DNA.[2] It has been widely used in synthesis of gold nanoparticles (e.g., spheres, rods, bipyramids), mesoporous silica nanoparticles (e.g., MCM-41), and hair conditioning products. The closely related compounds cetrimonium chloride and cetrimonium stearate are also used as topical antiseptics and may be found in many household products such as shampoos and cosmetics. CTAB, due to its relatively high cost, is typically only used in select cosmetics.
As with most surfactants, CTAB forms micelles in aqueous solutions. At 303 K (30 °C) it forms micelles with aggregation number 75–120 (depending on method of determination; average ~95) and degree of ionization, α = 0.2–0.1 (fractional charge; from low to high concentration).[3] The binding constant (K°) of Br− counterion to a CTA+ micelle at 303 K (30 °C) is c. 400 M-1. This value is calculated from Br− and CTA+ ion selective electrode measurements and conductometry data by using literature data for micelle size (r = ~3 nm)[citation needed], extrapolated to the critical micelle concentration of 1 mM[citation needed]. However, K° varies with total surfactant concentration so it is extrapolated to the point at which micelle concentration is zero.[citation needed]
^Laemmli, U. K. (1970-08-15). "Cleavage of structural proteins during the assembly of the head of bacteriophage T4". Nature. 227 (5259): 680–685. Bibcode:1970Natur.227..680L. doi:10.1038/227680a0. ISSN 0028-0836. PMID 5432063. S2CID 3105149.
^Clarke, Joseph D. (2009-03-01). "Cetyltrimethyl Ammonium Bromide (CTAB) DNA Miniprep for Plant DNA Isolation". Cold Spring Harbor Protocols. 2009 (3): pdb.prot5177. doi:10.1101/pdb.prot5177. ISSN 1940-3402. PMID 20147112.
^Bunton, Clifford A.; Nome, Faruk; Quina, Frank H.; Romsted, Laurence S. (1991-12-01). "Ion binding and reactivity at charged aqueous interfaces". Accounts of Chemical Research. 24 (12): 357–364. doi:10.1021/ar00012a001. ISSN 0001-4842.
and 29 Related for: Cetrimonium bromide information
Cetrimoniumbromide, also known with the abbreviation CTAB, is a quaternary ammonium surfactant with a condensed structural formula [(C16H33)N(CH3)3]Br...
chloride – an C25 structural analogue Cetrimoniumbromide – the corresponding bromide salt What is cetrimonium chloride? Archived 2012-03-04 at the Wayback...
cation whose salts are used as antiseptics:[citation needed] CetrimoniumbromideCetrimonium chloride They have the ATC codes D08AJ02 (WHO) (as skin antiseptics)...
alkyltrimethylammonium bromide, is an antiseptic which is a mixture of three quaternary ammonium compounds: tetradonium bromide (TTAB or MITMAB), cetrimoniumbromide (CTAB)...
solution. Some products are formulated instead with the bromide salt cetylpyridinium bromide, the properties of which are virtually identical.[citation...
have indicated that it does readily biodegrade. Cetrimoniumbromide – an C19 structural analogue Cetrimonium chloride – an C19 structural analogue Yamane...
the dichloride salt. It is useful as an antiseptic and disinfectant. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium...
reaction is used in analytical chemistry to confirm the presence of chloride, bromide, or iodide ions. Samples are typically acidified with dilute nitric acid...
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