Global InformationPolyhexanide information
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| Names | |
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| Other names
Polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide
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| Identifiers | |
CAS Number
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| Abbreviations | PHMB |
| ChEBI |
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| ChemSpider |
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| UNII |
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CompTox Dashboard (EPA)
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| Properties | |
Chemical formula
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(C8H17N5)n |
| Pharmacology | |
ATC code
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D08AC05 (WHO) S01AX24 (WHO) |
| Hazards | |
| GHS labelling:[1] | |
Pictograms
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Signal word
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Danger |
Hazard statements
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H302, H317, H318, H330, H351, H372, H410 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use,[2] it is spelled polihexanide (INN) and sold under the names Lavasept, Tebasept, Prontosan.[3] PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.[4]
Products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.[5] [6] PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.[7]
It is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The PHMB hydrochloride salt (solution) is used in the majority of formulations.
- ^ "Classification and Labelling of PHMB". European Chemicals Agency.
- ^ Ansorg R, Rath PM, Fabry W (2003). "Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin". Arzneimittel-Forschung. 53 (5): 368–71. doi:10.1055/s-0031-1297121. PMID 12854364. S2CID 33172373.
- ^ International Drug Names: Polihexanide
- ^ Maribeth Cousin, Kimberly Restivo, Chelsea Rodriguez, and Justin Lien. USP Antimicrobial Effectiveness Test (GLP). Elkhorn, WI: Geneva Laboratories. 2013. "Archived copy" (PDF). Archived from the original (PDF) on 4 March 2016. Retrieved 8 April 2015.
{{cite web}}: CS1 maint: archived copy as title (link) - ^ "Nusept". Archived from the original on 25 March 2012. Retrieved 8 June 2011.
- ^ Rippon MG, Rogers AA, Ousey K (2 January 2023). "Polyhexamethylene biguanide and its antimicrobial role in wound healing: a narrative review". J Wound Care. 32 (1): 5–20. doi:10.12968/jowc.2023.32.1.5.
- ^ Alkharashi M, Lindsley K, Law HA, Sikder S (2015). "Medical interventions for acanthamoeba keratitis". Cochrane Database Syst Rev. 2015 (2): CD0010792. doi:10.1002/14651858.CD010792.pub2. PMC 4730543. PMID 25710134.