Cefazolin, also known as cefazoline and cephazolin, is a first-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections.[2] Specifically it is used to treat cellulitis, urinary tract infections, pneumonia, endocarditis, joint infection, and biliary tract infections.[2] It is also used to prevent group B streptococcal disease around the time of delivery and before surgery.[2] It is typically given by injection into a muscle or vein.[2]
Common side effects include diarrhea, vomiting, yeast infections, and allergic reactions.[2] Historically, it was thought to be contraindicated in patients with allergies to penicillin, although several recent studies have refuted this and it is proven to be safe in almost all patients, including those with known penicillin allergies.[3] It is relatively safe for use during pregnancy and breastfeeding.[2][4] Cefazolin is in the first-generation cephalosporin class of medication and works by interfering with the bacteria's cell wall.[2]
Cefazolin was patented in 1967 and came into commercial use in 1971.[5][6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[2]
^ abcdefgh"Cefazolin Sodium". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
^"NEJM Journal Watch: Summaries of and commentary on original medical and scientific articles from key medical journals". www.jwatch.org. Retrieved 2023-01-20.
^Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 84. ISBN 9781284057560.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. Archived from the original on 2017-09-10.
^US patent 3516997, Takano T, Kurita M, Nikaido H, Mera M, Konishi N, Nakagawa R, "3,7-disubstituted cephalosporin compounds and preparation thereo", published 1970-06-23, issued 1970-06-23, assigned to Fujisawa Pharmaceutical Co Ltd
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Cefazolin, also known as cefazoline and cephazolin, is a first-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections...
works similarly to other agents within this class, including intravenous cefazolin, but can be taken by mouth. Cefalexin can treat certain bacterial infections...
Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with probenecid...
cefotetan are classed as second-generation cephalosporins. Cefalotin, cefazolin, cefalexin, cefapirin, cefradine, and cefadroxil are drugs belonging to...
intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agents cefalexin and cefadroxil. Cefalotin sodium is marketed...
and prochlorperazine, and broad-spectrum antibiotic injections such as cefazolin/enrofloxacin, ampicillin/enrofloxacin, metronidazole, timentin, or enrofloxacin...
may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and cloxacillin. Of patients with documented penicillin...
disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cefazolin Ancef, Kefzol Cephradine Cephapirin Cephalothin Cefalexin Keflex Cephalosporins...
sodium. The cephalosporin series includes intermediate 7-ACA, cefazolin sodium, cefazolin acid and ceftriaxone sodium. Meropenem API is also produced....
fractures and low velocity firearms injury. First generation cephalosporin (cefazolin) is recommended as first line antibiotics for the treatment of open fractures...
antibiotics. Rothia infections may be treated with penicillins, erythromycin, cefazolin, rifampin, aminoglycoside, tetracycline, chloramphenicol, and...
ceftazidime, potentially resulting in an explosive-like reaction in syringes. Cefazolin Ceforanide "Cefamandole sodium salt Susceptibility and 0.5 - 32 Minimum...
cultures should indicate clearly the presence of penicillin allergy. Cefazolin, clindamycin, and vancomycin are used to prevent EOD in infants born to...
"Comparative Effectiveness of Exclusive Exposure to Nafcillin or Oxacillin, Cefazolin, Piperacillin/Tazobactam, and Fluoroquinolones Among a National Cohort...
ceftriaxone Encef, a trade name in Turkey for cefdinir Ancef, a trade name for cefazolin This disambiguation page lists articles associated with the title Encef...
penicillin or a cephalosporin (low risk of anaphylaxis) could receive cefazolin (2 g IV initial dose, then 1 g IV every 8 hours until delivery) instead...
penicillin, you may need to use other antibiotics, such as clindamycin, cefazolin, or vancomycin. After giving birth, the official recommendation is to...
Certain other cephalosporin antibiotic medications, like cefotetan and cefazolin are metabolized to a compound that has similar effects at blocking acetaldehyde...
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