peptidase activator activity involved in apoptotic process
cysteine-type peptidase activity
HLA-A specific activating MHC class I receptor activity
endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
aminopeptidase activity
serine-type endopeptidase activity
hydrolase activity
thyroid hormone binding
peptidase activity
Cellular component
cytosol
alveolar lamellar body
lysosome
extracellular exosome
multivesicular body lumen
extracellular region
extracellular space
secretory granule lumen
intracellular membrane-bounded organelle
tertiary granule lumen
ficolin-1-rich granule lumen
cytoplasmic ribonucleoprotein granule
collagen-containing extracellular matrix
Biological process
surfactant homeostasis
antigen processing and presentation
adaptive immune response
bradykinin catabolic process
response to retinoic acid
membrane protein proteolysis
positive regulation of cell migration
ERK1 and ERK2 cascade
zymogen activation
neuropeptide catabolic process
positive regulation of epithelial cell migration
positive regulation of apoptotic signaling pathway
negative regulation of apoptotic process
proteolysis
positive regulation of angiogenesis
positive regulation of peptidase activity
positive regulation of gene expression
protein destabilization
cellular response to thyroid hormone stimulus
positive regulation of cell population proliferation
immune response-regulating signaling pathway
proteolysis involved in cellular protein catabolic process
metanephros development
dichotomous subdivision of terminal units involved in lung branching
T cell mediated cytotoxicity
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1512
13036
Ensembl
ENSG00000103811
ENSMUSG00000032359
UniProt
P09668
P49935
RefSeq (mRNA)
NM_004390 NM_148979 NM_001319137
NM_007801 NM_001312649
RefSeq (protein)
NP_001306066 NP_004381
NP_001299578 NP_031827
Location (UCSC)
Chr 15: 78.92 – 78.95 Mb
Chr 9: 89.94 – 89.96 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cathepsin H is a protein that in humans is encoded by the CTSH gene.[5][6]
The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000103811 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032359 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol Chem Hoppe-Seyler. 369 (6): 469–75. doi:10.1515/bchm3.1988.369.1.469. PMID 2849458.
CathepsinH is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease...
Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis...
presentation to the MHC class II. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. Cathepsin S is a lysosomal enzyme that...
Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene. This gene encodes a...
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked...
Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. The protein encoded by this gene is a cysteine cathepsin, a lysosomal...
Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup...
non-pepsin proteinase, cathepsin D-like acid proteinase, cathepsin E-like acid proteinase, cathepsin D-type proteinase) is an enzyme. Cathepsin E is a protease...
additional but weaker links to the loci of the genes TNFSF4 (rs7553711), CathepsinH (rs34593439), and P2RY11-DNMT1 (rs2305795). Another gene locus that has...
Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored...
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a...
cathepsin K. Studies on cathepsin L knockout mice have been mixed, with a report of reduced trabecular bone in homozygous and heterozygous cathepsin L...
peptide sequence. This sequence can be cleaved by cathepsin C, removing 2 amino acids. CathepsinH has also been reported to activate granzyme B. Granzyme...
Cathepsin F is a protein that in humans is encoded by the CTSF gene. Cysteine cathepsins are a family of cysteine proteases that represent a major component...
cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell...
stabilizes the histidine. Examples of cysteine aminopeptidases include cathepsinH and aminopeptidase B. In general, aminopeptidases play an important role...
disease of the bone caused by a mutation in the gene that codes the enzyme cathepsin K. It is also known as PKND and PYCD. The disease was first described...
Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene. The protein is a human cysteine...
Cathepsin zymography is a technique for quantifying enzymatic activity of the cathepsin family of cysteine proteases. It is based on SDS-PAGE whereby...
Cathepsin W is a protein that in humans is encoded by the CTSW gene. The protein encoded by this gene, a member of the peptidase C1 family of cysteine...
monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic...
Gallinamide A is potent and selective inhibitor of the human cysteine protease Cathepsin L1 that was first used as a moderate antimalarial agent. Gallinamide A...
Nitroxoline has been shown to inhibit the enzymatic activity of cathepsin B. Cathepsin B degrades extra-cellular membrane proteins in tumor cells, allowing...
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